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E-BookEPUBDRM AdobeE-Book
680 Seiten
Englisch
Elsevier Science & Techn.erschienen am26.07.20102. Auflage
Rabies is the most current and comprehensive account of one of the oldest diseases known that remains a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. During the past five years since publication of the first edition there have been new developments in many areas on the rabies landscape. This edition takes on a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of this disease. Current methods used in defining geographic origins and animal species infected in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. This multidisciplinary account is essential for clinicians as well as public health advisors, epidemiologists, wildlife biologists, and research scientists wanting to know more about the virus and the disease it causes.
* Offers a unique global perspective on rabies where dog rabies is responsible for killing more people than yellow fever, dengue fever, or Japanese encephalitis
* More than 7 million people are potentially exposed to the virus annually and about 50,000 people, half of them children, die of rabies each year
* New edition includes greatly expanded coverage of bat rabies which is now the most prominent source of human rabies in the New World and Western Europe, where dog rabies has been controlled
* Recent successes of controlling wildlife rabies with an emphasis on prevention is discussed
* Approximately 40% updated material incorporates recent knowledge on new approaches to therapy of human rabies as well as issues involving organ and tissue transplantation
* Includes an increase in illustrations to more accurately represent this diseases' unique horror

Dr. Jackson is Professor of Medicine (Neurology) and of Medical Microbiology and also Head of the Section of Neurology at University of Manitoba in Winnipeg, Manitoba, Canada. He graduated from Queen's University with BA and MD degrees. He completed an internship in internal medicine at University of Southern California, residencies in internal medicine at Queen's University and in neurology at the University of Western Ontario, and a fellowship in neurovirology at The Johns Hopkins University with Drs. Richard Johnson and Diane Griffin. Dr. Jackson held a faculty position at Queen's University from 1987 - 2007. He is on the Editorial Boards of the Journal of NeuroVirology and the Canadian Journal of Neurological Sciences. He is President of Rabies in the Americas, Inc. and is on the Board of Directors of the International Society for Neurovirology. Dr. Jackson is the principal investigator on research grants to study experimental aspects of rabies.
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KlappentextRabies is the most current and comprehensive account of one of the oldest diseases known that remains a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. During the past five years since publication of the first edition there have been new developments in many areas on the rabies landscape. This edition takes on a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of this disease. Current methods used in defining geographic origins and animal species infected in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. This multidisciplinary account is essential for clinicians as well as public health advisors, epidemiologists, wildlife biologists, and research scientists wanting to know more about the virus and the disease it causes.
* Offers a unique global perspective on rabies where dog rabies is responsible for killing more people than yellow fever, dengue fever, or Japanese encephalitis
* More than 7 million people are potentially exposed to the virus annually and about 50,000 people, half of them children, die of rabies each year
* New edition includes greatly expanded coverage of bat rabies which is now the most prominent source of human rabies in the New World and Western Europe, where dog rabies has been controlled
* Recent successes of controlling wildlife rabies with an emphasis on prevention is discussed
* Approximately 40% updated material incorporates recent knowledge on new approaches to therapy of human rabies as well as issues involving organ and tissue transplantation
* Includes an increase in illustrations to more accurately represent this diseases' unique horror

Dr. Jackson is Professor of Medicine (Neurology) and of Medical Microbiology and also Head of the Section of Neurology at University of Manitoba in Winnipeg, Manitoba, Canada. He graduated from Queen's University with BA and MD degrees. He completed an internship in internal medicine at University of Southern California, residencies in internal medicine at Queen's University and in neurology at the University of Western Ontario, and a fellowship in neurovirology at The Johns Hopkins University with Drs. Richard Johnson and Diane Griffin. Dr. Jackson held a faculty position at Queen's University from 1987 - 2007. He is on the Editorial Boards of the Journal of NeuroVirology and the Canadian Journal of Neurological Sciences. He is President of Rabies in the Americas, Inc. and is on the Board of Directors of the International Society for Neurovirology. Dr. Jackson is the principal investigator on research grants to study experimental aspects of rabies.
Details
Weitere ISBN/GTIN9780080550091
ProduktartE-Book
EinbandartE-Book
FormatEPUB
Format HinweisDRM Adobe
Erscheinungsjahr2010
Erscheinungsdatum26.07.2010
Auflage2. Auflage
Seiten680 Seiten
SpracheEnglisch
Dateigrösse14461 Kbytes
Artikel-Nr.2743716
Rubriken
Genre9200

Inhalt/Kritik

Inhaltsverzeichnis
1;Front cover;1
2;Rabies;4
3;Copyright page;5
4;Contents;6
5;Foreword;11
6;Preface;18
7;Contributors;19
8;Chapter 1 The History of Rabies;22
8.1;1 Introduction;22
8.2;2 Remedies for dog rabies from the early and middle ages to the 18th century;23
8.3;3 Rabies in the New World;27
8.4;4 The early role of wild animals in the spread of rabies;28
8.5;5 Development of the first-generation rabies vaccine;32
8.6;References;40
9;Chapter 2 Rabies Virus;44
9.1;1 Introduction;44
9.2;2 Rabies virus structure;45
9.3;3 Rabies virus replication;50
9.4;4 Life cycle of rabies virus infection;54
9.5;5 Virus cell-to-cell spread - perpetuating the virus life cycle;62
9.6;6 Structure of rabies virus proteins in relation to function;63
9.7;References;77
10;Chapter 3 Molecular Epidemiology;90
10.1;1 Introduction;90
10.2;2 Methods and definition of terms;91
10.3;3 Viral taxonomy;117
10.4;4 Aspects of rabies pathogenesis and evolution revealed by molecular epidemiology;131
10.5;5 Conclusions and future trends;135
10.6;Acknowledgments;136
10.7;References;136
11;Chapter 4 Epidemiology;144
11.1;1 Introduction to concepts;144
11.2;2 The epidemiology of human rabies;150
11.3;3 Routes of rabies virus transmission to humans;164
11.4;4 Risk and prevention of rabies following an exposure;165
11.5;5 Epidemiology of rabies in mammalian populations;168
11.6;6 Dissemination of canine rabies and evidence for periodic cycles;176
11.7;7 Cross-species transmission (spillover) of rabies virus;178
11.8;8 Spatial spread and epidemiology of wildlife rabies;187
11.9;9 Control of rabies directed toward mammalian reservoir hosts;193
11.10;References;201
12;Chapter 5 Rabies in Terrestrial Animals;222
12.1;1 Introduction;222
12.2;2 Host range and susceptibility;224
12.3;3 Transmission;231
12.4;4 Clinical course;232
12.5;5 Differential diagnosis;235
12.6;6 Viral excretion and public health implications;235
12.7;7 Reservoirs and other lyssaviruses;237
12.8;8 Rabies in domestic animals;237
12.9;9 Wildlife reservoirs;247
12.10;10 Other animals as reservoirs or simply spillover hosts?;263
12.11;11 Conclusions;266
12.12;References;267
13;Chapter 6 Bat Rabies;280
13.1;1 Introduction - general considerations on bat rabies;280
13.2;2 Bat rabies in the New World;282
13.3;3 Bat rabies in the Old World;298
13.4;References;320
14;Chapter 7 Human Disease;330
14.1;1 Introduction;330
14.2;2 Exposures, incubation period and prodromal symptoms;330
14.3;3 Clinical forms of disease;335
14.4;4 Investigations;340
14.5;5 Differential diagnosis;344
14.6;6 Therapy;345
14.7;7 Recovery from rabies;346
14.8;8 Rabies due to other Lyssavirus genotypes;350
14.9;References;354
15;Chapter 8 Pathogenesis;362
15.1;1 Introduction;362
15.2;2 Events at the site of exposure;362
15.3;3 Spread to the CNS;369
15.4;4 Spread within the CNS;370
15.5;5 Spread from the CNS;371
15.6;6 Animal models of rabies virus neurovirulence;372
15.7;7 Rabies virus receptors;375
15.8;8 Brain dysfunction in rabies;377
15.9;9 Recovery from rabies and chronic rabies virus infection;389
15.10;10 Summary;392
15.11;References;393
16;Chapter 9 Pathology;404
16.1;1 Introduction;404
16.2;2 Macroscopic findings;404
16.3;3 Pathology in the central nervous system;405
16.4;4 Pathology in the peripheral nervous system;418
16.5;5 Pathology involving the eye and extraneural organs;422
16.6;6 Summary and conclusions;424
16.7;References;424
17;Chapter 10 Diagnostic Evaluation;432
17.1;1 Introduction;432
17.2;2 Post-mortem diagnosis of rabies in animals;434
17.3;3 Virus isolation;450
17.4;4 Use of molecular methods to detect viral RNA;451
17.5;5 Diagnosis of rabies in humans;474
17.6;6 Rabies antibody assays;480
17.7;Acknowledgements;483
17.8;References;483
18;Chapter 11 Rabies Serology;492
18.1;1 Introduction;492
18.2;2 Investigative serology;493
18.3;3 Serologic methods;495
18.4;4 Choosing an assay;501
18.5;5 Quality assurance measures;504
18.6;6 Conclusions;507
18.7;References;507
19;Chapter 12 Immunology;510
19.1;1 Introduction;510
19.2;2 Molecular components of a specific immune response;510
19.3;3 Immune responses during RABV infection;512
19.4;4 Immunological basis for post-exposure vaccination efficiency;519
19.5;5 Conclusions;522
19.6;References;522
20;Chapter 13 Human Rabies Vaccines;526
20.1;1 Introduction;526
20.2;2 Value of vaccination;527
20.3;3 Nerve tissue vaccines;529
20.4;4 Cell culture vaccines;530
20.5;5 Conclusions;534
20.6;References;534
21;Chapter 14 Animal Vaccines;538
21.1;1 Introduction;538
21.2;2 Animal rabies vaccines;538
21.3;References;548
22;Chapter 15 Next Generation Rabies Vaccines;552
22.1;1 Introduction;552
22.2;2 Recombinant virus vaccines;552
22.3;3 DNA-based rabies vaccines;558
22.4;4 Oral rabies vaccines derived from plants;560
22.5;References;561
23;Chapter 16 Public Health Management of Humans at Risk;566
23.1;1 Introduction;566
23.2;2 Pre-exposure vaccination;569
23.3;3 Post-exposure vaccination;574
23.4;4 Adverse reactions to cell culture vaccines;582
23.5;5 Interchangeability of vaccines;582
23.6;6 Rabies in children;583
23.7;7 Travel to canine rabies endemic countries;584
23.8;8 Rabies control in developing countries;585
23.9;9 Educational awareness;586
23.10;References;587
24;Chapter 17 Dog Rabies and its Control;594
24.1;1 Introduction;594
24.2;2 The burden of canine rabies;594
24.3;3 Historical perspectives on dog rabies control;597
24.4;4 Dog accessibility;599
24.5;5 Vaccination coverage;601
24.6;6 The epidemiological theory of dog rabies control;603
24.7;7 Oral vaccination of dogs;605
24.8;8 Age at first vaccination;606
24.9;9 Dog rabies control in wildlife conservation;607
24.10;10 Economics of dog vaccination for rabies control;608
24.11;11 Dog population management;609
24.12;12 Conclusion;610
24.13;Acknowledgements;611
24.14;References;611
25;Chapter 18 Rabies Control in Wild Carnivores;616
25.1;1 Introduction;616
25.2;2 Historical aspects of rabies control in wildlife;616
25.3;3 The concept of controlling rabies in wildlife;620
25.4;4 Initiation of wildlife rabies control programs;621
25.5;5 Diagnosis of suspect wildlife;623
25.6;6 Vector species biology in relation to rabies epidemiology;623
25.7;7 Transportation of wildlife;624
25.8;8 Point infection control: the first callfor control;624
25.9;9 Bait development for delivery of oralrabies vaccine;626
25.10;10 ORV initiation/considerations;627
25.11;11 Importance of vector home range and density for vaccine bait distribution;633
25.12;12 Large-scale vaccine bait distribution technology;634
25.13;13 Surveillance prior to, during and after a rabies control program;635
25.14;14 Vaccine baiting costs/benefits and costs of rabies control;639
25.15;15 Vaccine baiting efficiency and baiting success guidelines;640
25.16;16 Contingency planning;642
25.17;17 Modeling;642
25.18;18 Conclusion;644
25.19;References;645
26;Chapter 19 Future Developments and Challenges;656
26.1;1 Introduction;656
26.2;2 Pathogenesis;656
26.3;3 Epidemiology;657
26.4;4 Prevention of human rabies;658
26.5;5 Diagnosis and therapy of human rabies;659
26.6;6 Control of animal rabies;660
26.7;7 Summary;662
26.8;References;662
27;Index;666
27.1;A;666
27.2;B;667
27.3;C;668
27.4;D;669
27.5;E;670
27.6;F;671
27.7;G;671
27.8;H;672
27.9;I;672
27.10;J;673
27.11;K;673
27.12;L;673
27.13;M;674
27.14;N;675
27.15;O;675
27.16;P;676
27.17;Q;677
27.18;R;677
27.19;S;679
27.20;T;679
27.21;U;680
27.22;V;680
27.23;W;681
27.24;Z;681
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