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Handbook of Stress and the Brain Part 1: The Neurobiology of Stress

E-BookEPUBDRM AdobeE-Book
856 Seiten
Englisch
Elsevier Science & Techn.erschienen am25.02.2005
The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system, how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run.
Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry.


Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality.

* Provides an overview of recent advances made in stress research
* Includes timely discussion of stress and its effect on the immune system
* Presents novel treatment strategies targeting brain processes involved in stress processing and coping mechanismsmehr
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EUR299,50
E-BookEPUBDRM AdobeE-Book
EUR220,00

Produkt

KlappentextThe Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system, how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run.
Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry.


Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality.

* Provides an overview of recent advances made in stress research
* Includes timely discussion of stress and its effect on the immune system
* Presents novel treatment strategies targeting brain processes involved in stress processing and coping mechanisms
Details
Weitere ISBN/GTIN9780080553245
ProduktartE-Book
EinbandartE-Book
FormatEPUB
Format HinweisDRM Adobe
Erscheinungsjahr2005
Erscheinungsdatum25.02.2005
Seiten856 Seiten
SpracheEnglisch
Artikel-Nr.2746361
Rubriken
Genre9200

Inhalt/Kritik

Inhaltsverzeichnis
1;Front Cover ;1
2;Handbook of Stress and the Brain: The Neurobiology of Stress;4
3;Copyright Page ;5
4;Contents;16
5;List of Contributors;6
6;Preface;12
7;A Memorial for David de Wied (1925-2004);14
8;Section 1: Concepts of Stress;20
8.1;Chapter 1.1. Stress: an historical perspective;22
8.2;Chapter 1.2. The neuropsychology of stress;44
8.3;Chapter 1.3. An introduction to the HPA axis;62
8.4;Chapter 1.4. Hormones of the pituitary;86
8.5;Chapter 1.5. Molecular biology of the HPA axis;98
8.6;Chapter 1.6. The hypothalamic-pituitary-adrenal axis as a dynamically organized system: lessons from exercising mice;114
9;Section 2: Hypothalamic Hormones Involved in Stress Responsivity;132
9.1;Chapter 2.1. Novel CRF family peptides and their receptors: an evolutionary analysis;134
9.2;Chapter 2.2. Molecular regulation of the CRF system;152
9.3;Chapter 2.3. Behavioral consequences of altered corticotropin-releasing factor activation in brain: a functionalist view of affective neuroscience;174
9.4;Chapter 2.4. The roles of urocortins 1, 2, and 3 in the brain;198
9.5;Chapter 2.5. Vasopressin and oxytocin;224
9.6;Chapter 2.6. The role of vasopressin in behaviors associated with aversive stimuli;250
10;Section 3: Stress and the HPA Axis;282
10.1;Chapter 3.1. Corticosteroid receptors and HPA-axis regulation;284
10.2;Chapter 3.2. Glucocorticoid effects on gene expression;314
10.3;Chapter 3.3. The role of 11ß-hydroxysteroid dehydrogenases in the regulation of corticosteroid activity in the brain;332
10.4;Chapter 3.4. Corticosteroids and the blood-brain barrier;348
10.5;Chapter 3.5. Glucocorticoids and motivated behaviour;360
10.6;Chapter 3.6. Effects of glucocorticoids on emotion and cognitive processes in animals;378
10.7;Chapter 3.7. Glucocorticoids: effects on human cognition;406
11;Section 4: Neurotransmitter Systems Involved in Stress Responsivity;422
11.1;Chapter 4.1. Neurocircuit regulation of the hypothalamo-pituitary-adrenocortical stress response - an overview;424
11.2;Chapter 4.2. Sympatho-adrenal activity and hypothalamic-pituitary-adrenal axis regulation;438
11.3;Chapter 4.3. The locus coeruleus-noradrenergic system and stress: modulation of arousal state and state-dependent behavioral processes;456
11.4;Chapter 4.4. Functional interactions between stress neuromediators and the locus coeruleus-norepinephrine system;484
11.5;Chapter 4.5. Regional specialisation in the central noradrenergic response to unconditioned and conditioned environmental stimuli;506
11.6;Chapter 4.6. Stress, corticotropin-releasing factor and serotonergic neurotransmission;522
11.7;Chapter 4.7. Modulation of glutamatergic and GABAergic neurotransmission by corticosteroid hormones and stress;544
11.8;Chapter 4.8. Neuroactive steroids;564
11.9;Chapter 4.9. Endogenous opioids, stress, and psychopathology;580
11.10;Chapter 4.10. Acetylcholinesterase as a window onto stress responses;604
11.11;Chapter 4.11. Pathways and transmitter interactions mediating an integrated stress response;628
12;Section 5: Neuroplasticity and Stress;660
12.1;Chapter 5.1. The intracellular signaling cascade and stress;662
12.2;Chapter 5.2. The role of neurotrophic factors in the stress response;684
12.3;Chapter 5.3. Transcription factors as modulators of stress responsivity;698
12.4;Chapter 5.4. Experience, structural plasticity and neurogenesis;718
12.5;Chapter 5.5. Adult neurogenesis in rodents and primates: functional implications;730
12.6;Chapter 5.6. Cellular and molecular analysis of stress-induced neurodegeneration - methodological considerations;748
12.7;Chapter 5.7. Enhancing resilience to stress: the role of signaling cascades;770
13;Section 6: The Stressed Brain;792
13.1;Chapter 6.1. Psychological and physiological stressors;794
13.2;Chapter 6.2. Involvement of the amygdala in the neuroendocrine and behavioral consequences of stress;812
13.3;Chapter 6.3. Role of prefrontal cortex in stress responsivity;826
14;Subject Index;838mehr
Leseprobe

Chapter 1.1
Stress: an historical perspective

Seymour Levine*    Department of Psychiatry, Center for Neuroscience, University of California, Davis, California 95616, USA
* Tel.: + 1530 752 1887; Fax: + 1530 757 8827; email address: slevine@ucdavis.edu

Abstract

Some of the major landmarks in the history of neuroendocrinology, glucocorticoid physiology and psychoneuroendocrinology are discussed in this chapter. The primary emphasis is on the evolution of the major theories and their experimental underpinnings on the regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Initially an attempt was made to deal with the issues concerning the definitions of stress. The origins of the stress concept, the neural control of the pituitary, the history of the search for corticotrophin-releasing factor (CRF), and the developments that resulted in shaping the current views of the action of the adrenal hormones are elaborated. Further, the role of environment and behavior on the regulation of the HPA axis and the effects of specific neuropeptides on behavior were also covered. The purpose of this chapter is to provide a perspective on the major events that were crucial in the history of stress research that shaped the directions of the field.




The past is never dead. It s not even the past

William Faulkner


Introduction

During the course of my career, which now spans over five decades, I could not begin to count the number of conferences, workshops, and symposia related to stress that I have attended. I will not attempt to describe the number of times during these meeting that at least one, if not several, of the participants had championed the notion that we discard the concept for a more precise definition. The absolute failure of these attempts is attested to by my most recent visit to one of my favorite biomedical computer searches. As of this moment Pub-Med listed 209,744 references that in one way or another had some reference to the term stress. It would be difficult to predict what this number will be at the time this chapter is published. These staggering figures are at best an underestimate since computer searches rarely go beyond the late 1970s and publications in this field began long before this time. Further, the particular search that was used lists mostly articles and ignores the extensive list of books dedicated to this subject. What is also evident from the information obtained from the computer is that the number of publications is accelerating. Over 60,000 papers have been published since the beginning of the new millennium. A close examination of only a small sample of these references made it abundantly clear that the term stress was used in so many different ways that it would be necessary to determine, for each article listed, the precise manner the term was used and in what context. It would be further difficult to specify all the different disciplines that have in some way found the concept of stress useful, though each discipline will define stress in its own idiosyncratic manner.
Defining stress

After the completion of my last effort to define stress (Levine and Ursin, 1991), I made myself the promise that I would never again engage in what I consider a futile exercise. One of the more recent definitions was presented by McEwen (2000). Stress may be defined as a real or interpreted threat to the physiological or psychological integrity of an individual that results in physiological and/or behavioral responses. In biomedicine, stress often refers to situations in which adrenal glucocorticoids (GCs) and catecholamines are elevated because of an experience. Chrousos and Gold (1992) state we define stress as state of disharmony, or threatened homeostasis. The adaptive response can be specific or can be generalized and non specific. At the core of these definitions is the concept of homeostasis. Thus, some disturbance of homeostasis results in a cascade of physiological and/or behavioral responses that presumably are required to reinstate the ideal homeostatic balance.

However, these definitions as well as most others are problematic. As stated by Levine and Ursin (1991) The major problem with the concept of stress is that we are confronted with a composite, multidimensional concept. All existing definitions include some components. We can identify three main subclasses. These subclasses can be identified as the input (stress stimuli), the processing systems, including the subjective experience of stress and the output (stress responses). One basic difficulty is that these subclasses interact. The essential picture we want to convey is one of a complex system with feedback and control loops, no less but no more complicated than any other of the body s self-regulated systems. This system affects many other biological processes and may function as a common alarm and drive system, whenever there is a real or apparent challenge to the self-regulating systems of the organism.

Steptoe (2000) has suggested that the effects of stress are manifest in four distinct domains; physiology, behavior, subjective experience, and cognitive function. The physiological effects of stress include alterations in neuroendocrine, autonomic nervous system and immune function. If one were to isolate only the physiological effects of stress, the history of three major areas of investigation would need to be covered and this would not include the relationships or lack of relationship among these systems. This historical perspective will focus primarily on the neuroendocrine system and more specifically with the hypothalamic-pituitary-adrenal (HPA) axis. For this discussion we will use the more traditional designation HPA, although more recently we have seen a trend to label the axis as LHPA. The L stands for limbic system and is intended to indicate that the regulation of the hormonal cascade caused by exposure to stress involves extrahypothalamic structures. The aim of this chapter is to provide a glimpse into the historical events that have provided the framework, the insights, and the theories that in many ways still guide our current research.

Insofar as several papers will appear in subsequent volumes that deal extensively with many different aspects of the HPA axis, I will provide only a very simple description of some of the key elements in the neuroendocrine cascade that results in an increased secretion of adrenocorticotropic hormone (ACTH), and that ultimately results in elevations of the levels of GCs. Some environmental event which involves either physical demands or is psychologically challenging or a combination of both, induces an increase in the release of corticotrophin-releasing factor (CRF) and arginine vasopressin (AVP) into the portal circulation. CRF/AVP then activates the corticotrophs in the pituitary to release ACTH into the general circulation. ACTH acts upon the adrenal cortex to induce synthesis and increased secretion of the GCs. Under normal circumstances these elevated levels of GC activate the GC receptors which serve to terminate the release of CRF and ACTH, thus returning the organism to its basal state.

Traditionally, a discourse on the history of this or any other field would trace the evolution of the critical components along some time dimension. If I were to take this approach the result would simply be a compilation of the information contained in many other sources. Since history does unfold through time it is difficult to avoid using a temporal framework. However, I intend to trace this history as it unfolded in my academic lifetime and how it influenced and shaped the field as we know it today. This will be an historical perspective, but the perspective will be autobiographical.
Not so ancient history

As was stated earlier I will not attempt to present all the details of the variety of thought and experimental evidence that eventually leads us to the 21st century views of stress. The earliest references to the concept of homeostasis come from the Greek philosophers and physicians, in particular, Hippocrates. This is best summarized by Chrousos et al. (1988). What is important is that the concepts of harmony and disharmony (homeostasis?) of man and animals with both the external and internal environment have long been a concern of serious thinkers. The concept of stress was originally taken from the dynamics of physics to describe the relationship between stress and strain in an elastic body. The term stress is applied to the mutual actions which take place across any section of a body to which a system of forces is applied. The term strain is applied to any changes occurring in the dimension or shape of a body when forces are applied (Duncan and Starling, 1959).

However, our current interest in and views on the physiology and psychology of stress are of more recent vintage and can be traced primarily to the contributions of Walter B. Cannon (1914, 1915, 1932) and Hans Selye (1950, 1956). The overarching principles that emerged from the studies by Cannon and Selye were: (1) there was a physiology that was specific to stress and (2) that an integral part of this physiology was related to some function of the adrenal. Although both emphasized the role of the adrenal, there was a clear distinction between them. (1) Cannon focused primarily on the sympathetic nervous system, including the adrenal medulla, and the role of the...
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