Hugendubel.info - Die B2B Online-Buchhandlung 

Merkliste
Die Merkliste ist leer.
Bitte warten - die Druckansicht der Seite wird vorbereitet.
Der Druckdialog öffnet sich, sobald die Seite vollständig geladen wurde.
Sollte die Druckvorschau unvollständig sein, bitte schliessen und "Erneut drucken" wählen.

Radical and Radical Ion Reactivity in Nucleic Acid Chemistry

Wileyerschienen am01.07.2009
Comprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry
The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective.

The chemistry and biochemistry of reactive intermediates is central to organic chemistry and biochemistry, and underlies a significant portion of modern synthetic chemistry. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates.

With contributions by world leaders in the field, the text covers a broad range of topics, including:
A discussion of the relevant theory
Ionization of DNA
Nucleic acid sugar radicals
Halopyrimidines
Oxidative, reductive, and low energy electron transfer
Electron affinity sensitizers
Photochemical generative of reactive oxygen species
Reactive nitrogen species
Enediyne rearrangements
Phenoxyl radicals
A unique compilation on the cutting edge of our understanding, Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides an unparalleled resource to student and professional researchers in such fields as organic chemistry, biochemistry, molecular biology, and physical chemistry, as well as the industries associated with these disciplines.

Marc M. Greenberg is a Professor of Chemistry and Director of the Chemistry Biology Interface Graduate Training Program at Johns Hopkins University. His research uses chemistry, biochemistry, and biology to fundamentally understand how DNA is oxidatively damaged, and what the effects of that damage are.
Steven E. Rokita, PhD, is Professor in the Department of Chemistry and Biochemistry at the University of Maryland. His research interests lie in sequence and conformation specific reactions of nucleic acids, enzyme-mediated activation of substrates and coenzymes, halogenation and dehalogenation reactions in biology, aromatic substitution and quinone methide generation in bioorganic chemistry, and copper- and nickel-mediated reactions in bioinorganic chemistry.
mehr
Verfügbare Formate
BuchGebunden
EUR173,50

Produkt

KlappentextComprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry
The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective.

The chemistry and biochemistry of reactive intermediates is central to organic chemistry and biochemistry, and underlies a significant portion of modern synthetic chemistry. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates.

With contributions by world leaders in the field, the text covers a broad range of topics, including:
A discussion of the relevant theory
Ionization of DNA
Nucleic acid sugar radicals
Halopyrimidines
Oxidative, reductive, and low energy electron transfer
Electron affinity sensitizers
Photochemical generative of reactive oxygen species
Reactive nitrogen species
Enediyne rearrangements
Phenoxyl radicals
A unique compilation on the cutting edge of our understanding, Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides an unparalleled resource to student and professional researchers in such fields as organic chemistry, biochemistry, molecular biology, and physical chemistry, as well as the industries associated with these disciplines.

Marc M. Greenberg is a Professor of Chemistry and Director of the Chemistry Biology Interface Graduate Training Program at Johns Hopkins University. His research uses chemistry, biochemistry, and biology to fundamentally understand how DNA is oxidatively damaged, and what the effects of that damage are.
Steven E. Rokita, PhD, is Professor in the Department of Chemistry and Biochemistry at the University of Maryland. His research interests lie in sequence and conformation specific reactions of nucleic acids, enzyme-mediated activation of substrates and coenzymes, halogenation and dehalogenation reactions in biology, aromatic substitution and quinone methide generation in bioorganic chemistry, and copper- and nickel-mediated reactions in bioinorganic chemistry.
Details
Weitere ISBN/GTIN9780470526262
ProduktartE-Book
EinbandartE-Book
FormatPDF
Verlag
Erscheinungsjahr2009
Erscheinungsdatum01.07.2009
Seiten400 Seiten
SpracheEnglisch
Dateigrösse11627
Artikel-Nr.3114731
Rubriken
Genre9201

Inhalt/Kritik

Inhaltsverzeichnis
Preface to Series vii

Introduction ix

Contributors xi

1. Theoretical Modeling of Radiation-Induced DNA Damage 1

Anil Kumar and Michael D. Sevilla

2. Radical Reaction Pathways Initiated by Direct Energy
Deposition in DNA by Ionizing Radiation 41

William A. Bernhard

3. Chemical Reactions of the Radical Cations of Nucleobases in
Isolated and Cellular DNA. Formation of Single-Base Lesions
69

Jean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat,
and J. Richard Wagner

4. Reactivity of Nucleic Acid Sugar Radicals 99

Chryssostomos Chatgilialoglu

5. Pyrimidine Nucleobase Radical Reactivity 135

Marc M. Greenberg

6. Reactivity of 5-Halopyrimidines in Nucleic Acids 163

Ryu Tashiro and Hiroshi Sugiyama

7. Kinetics of Long-Range Oxidative Electron Transfer Through
DNA 191

Kiyohiko Kawai and Tetsuro Majima

8. Radical Intermediates During Reductive Electron Transfer
Through DNA 211

Reji Varghese and Hans-Achim Wagenknecht

9. Low-Energy Electron Interaction with DNA: Bond Dissociation
and Formation of Transient Anions, Radicals, and Radical Anions
239

Leon Sanche

10. Electronic-Affinic Radiosensitizers 295

Peter Wardman

11. Reactions of Reactive Nitrogen Species and Carbonate Radical
Anions with DNA 325

Vladimir Shafirovich, Conor Crean, and Nicholas E.
Geacintov

12. Principles and Applications of Electrochemical Oxidation of
Nucleic Acids 357

H. Holden Thorp and Julie M. Sullivan

13. DNA Damage Due to Diradical-Generating Cyclizations
389

Sean M. Kerwin

14. DNA Damage by Phenoxyl Radicals 421

Richard A. Manderville

Index 445
mehr

Autor

Marc M. Greenberg is a Professor of Chemistry and Director
of the Chemistry Biology Interface Graduate Training Program at
Johns Hopkins University. His research uses chemistry,
biochemistry, and biology to fundamentally understand how DNA is
oxidatively damaged, and what the effects of that damage are.

Steven E. Rokita, PhD, is Professor in the Department of
Chemistry and Biochemistry at the University of Maryland. His
research interests lie in sequence and conformation specific
reactions of nucleic acids, enzyme-mediated activation of
substrates and coenzymes, halogenation and dehalogenation reactions
in biology, aromatic substitution and quinone methide generation in
bioorganic chemistry, and copper- and nickel-mediated reactions in
bioinorganic chemistry.