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Diuretics

E-BookPDF1 - PDF WatermarkE-Book
517 Seiten
Englisch
Springer Berlin Heidelbergerschienen am06.12.20121995
The action of diuretics including cellular mechanisms of action, pharmacokinetics, and clinical usage, with much emphasis placed on the most recent findings on the pharmacodynamics of the respective drugs. During the past twenty-five years since volume 14 on Diuretica was published in the Handbook series, the cellular mechanisms of action of diuretics have slowly been unravelled. Today, the role of action within the target cells is known for most of the substances discussed. This has provided a new basis not only for the understanding of drug action but also for secondary effects and interactions. The book represents a comprehensive reference work on the diverse groups of diuretics which are among the most frequently prescribed medications.mehr

Produkt

KlappentextThe action of diuretics including cellular mechanisms of action, pharmacokinetics, and clinical usage, with much emphasis placed on the most recent findings on the pharmacodynamics of the respective drugs. During the past twenty-five years since volume 14 on Diuretica was published in the Handbook series, the cellular mechanisms of action of diuretics have slowly been unravelled. Today, the role of action within the target cells is known for most of the substances discussed. This has provided a new basis not only for the understanding of drug action but also for secondary effects and interactions. The book represents a comprehensive reference work on the diverse groups of diuretics which are among the most frequently prescribed medications.
Details
Weitere ISBN/GTIN9783642795657
ProduktartE-Book
EinbandartE-Book
FormatPDF
Format Hinweis1 - PDF Watermark
FormatE107
Erscheinungsjahr2012
Erscheinungsdatum06.12.2012
Auflage1995
ReiheHandbook of Experimental Pharmacology
Reihen-Nr.117
Seiten517 Seiten
SpracheEnglisch
IllustrationenXXI, 517 p.
Artikel-Nr.7451827
Rubriken
Genre9200

Inhalt/Kritik

Inhaltsverzeichnis
1 :Functional Anatomy of the Kidney.- A.Structural Organization of the Kidney.- B.General Organization of Renal Epithelia and Correlation with Transport.- C.Nephron and Collecting Duct Structure.- D.Alterations of Morphology in Electrolyte Disturbances.- References.- 2 : Basic Concepts of Renal Physiology.- A.Introduction.- B.Renal Blood Flow and Glomerular Filtration.- C.Renal Tubular Transport.- D.Regulation of Renal Water and Electrolyte Excretion.- References.- 3 : Renal Energy Metabolism.- A.Introduction.- B.Mechanisms of Renal ATP Formation.- C.Metabolic Substrates of Renal Energy Metabolism.- D.Regulation of ATP in Tubule Cells.- E.Interaction of Diuretic Substances with Renal Energy Metabolism.- References.- 4 : Discovery and Development of Diuretic Agents.- A.Introduction.- B.Xanthine Derivatives.- C.Osmotic Diuretics.- D.Mercurial Diuretics.- E.Carbonic Anhydrase Inhibitors.- F.Sulfonamide Diuretics.- G.Nonsulfonamide Diuretics.- H. So-called Polyvalent Diuretics.- I. Aquaretics.- J. New Aspects: Ion Transport Modulators.- References.- 5 :Metabolism of Diuretics.- A.Introduction.- B.Biotransformation.- C.Patterns of Biotransformation.- D.Biotransformation of Diuretics.- References.- 6 :Interaction of Diuretics with Transport Systems in the Proximal Renal Tubule.- A.Introduction.- B.Transport System for Hydrophobic Organic Anions (pflra-Aminohippurate).- C.Transport Systems for Organic Cations.- D.Transport Systems for Sulfate.- E.Transport Systems for Dicarboxylates.- F.Interaction of Diuretics with the Different Proximal Transport Systems.- G.How Does Metabolic Transformation Change the Interaction with the Transport Systems for Organic Anions and Cations?.- References.- 7 :Loop Diuretics.- A.Introduction.- B.The Heterogeneous Group of Loop Diuretics.- C.Organotropy of Loop Diuretics.- D.Saluretic and Diuretic Effects of Loop Diuretics and Cellular Mechanisms.- E.Effects of Loop Diuretics in the Intact Kidney.- G.Pharmacokinetics.- H. Pharmacokinetics and Pharmacodynamics.- I. Clinical Uses.- J. Adverse Effects.- References.- 8 :Thiazide Diuretics.- A.Introduction.- B.Chemical Structures.- C.Pharmacokinetics.- D.Pharmacodynamics.- E.Pharmacokinetics in Disease States.- F.Saluretic Effects of Thiazides.- G.Diuretics in Nonedematous States.- H. Side Effects of Diuretic Therapy.- I. Drug Combinations.- References.- 9 :Potassium-Retaining Diuretics: Aldosterone Antagonists.- A. Chemical Structure and Properties, Structure-Activity Relationships of Aldosterone Antagonists.- B.Pharmacodynamics.- C.Pharmacokinetics.- D.Therapeutic Use (Indications, Dosage, Contraindications).- E.Side Effects and Toxicology.- F. Drug Interactions.- References.- 10 :Potassium-Retaining Diuretics: Amiloride.- A.Introduction.- B.Structure-Function Relationships.- C.Pharmacodynamics.- D.Pharmacokinetics.- E.Therapeutic Use.- F.Side Effects and Toxicity.- G. Drug Interactions.- References.- 11 :Potassium-Retaining Diuretics: Triamterene.- A.Chemical Structure and Properties.- B.Pharmacodynamics.- C.Pharmacokinetics.- D.Therapeutic Use.- I. Indications.- II. Dosage.- III. Side Effects.- IV. Contraindications.- V. Drug Interactions.- E.Toxicity.- References.- 12 :Osmotic Diuretics: Mannitol.- A.Introduction.- B.Renal Effects.- IV. Transport of Other Ions.- V. Urinary Concentration and Dilution.- VI. Miscellaneous Effects.- C.Beneficial Extrarenal Effects of Hypertonic Mannitol.- D.Effects on the Cardiovascular System.- E.Clinical Use.- References.- 13 :Clinical Uses of Diuretics.- A.Introduction.- B.Physiological Basis of Diuretic Action and Clinical Implications of Physiological Principles.- C.Diuretics in the Treatment of Edematous States and Disorders Associated with Abnormalities of Renal Function.- D.Diuretics in the Treatment of Nonedematous Disorders.- E. Diuretic Side Effects and Adverse Reactions.- References.mehr