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Nanotechnology in Therapeutics

Basics and Trends
Wileyerschienen am01.07.2024
Nanotechnology in Therapeutics
Comprehensive reference delivering a framework to develop and assess nanosystems that provide unique advantages in biomedical applications
Nanotechnology in Therapeutics explores the idea that by studying in depth the behavior of living organisms, especially the functionality of their cell membranes, we can develop and evaluate innovative bio-inspired nanosystems that are able to deliver small molecules, biomolecules like proteins, peptides, and other genetic material in terms of the production of new therapies and vaccines. The main concept promoted in this book is an integrated approach for producing new medicines following the nanotoxicity, biotoxicity, regulatory, and ethical guidelines, which are also covered in the book.
The book is divided into three parts. Part A provides an introduction and a historical overview of nanotechnology. Part B delves deeper into issues relating to lipid and polymeric nanostructures in medicine. Part C presents the regulatory landscape around nanotechnology and nanomedicine, while highlighting the need to keep an eye on emerging technologies such as artificial intelligence and machine learning. Overall, this book opens up biomedical applications for previously challenging drugs and drug targets.
Written by a highly qualified professor with significant pertinent research experience, Nanotechnology in Therapeutics includes discussion on: Eukaryotic cell membranes, their structural properties, and the thermodynamic payload of their lipid bilayers
The DLVO (Derjaguin, Landau, Verwey and Overbeek) theory as a scientific tool for studying the stability and the behavior of nanoparticles
Liposomes, lipid nanoparticles, and solid lipid nanoparticles, as well as polymeric nanoparticles, like micelles, polymersomes, and dendrimers
Issues in the approval process of nanomedicines by the regulatory agencies, such as complexity, chaos, and nonlinear dynamics

With comprehensive coverage of novel concepts that have the potential to transform how new medicines are designed and developed, Nanotechnology in Therapeutics is an essential resource on the subject for chemists in industry, as well as biomedical and pharmaceutical engineers.


Costas Demetzos is Professor of Pharmaceutical Nanotechnology at the National and Kapodistrian University of Athens. Currently, Prof. Demetzos serves as Director of the Laboratory of Pharmaceutical Technology, and since 2008 he serves as President of the Hellenic Pharmaceutical Society (HPS). His research interests include pharmaceutical nanotechnology, nanomedicine, and thermodynamics.
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Produkt

KlappentextNanotechnology in Therapeutics
Comprehensive reference delivering a framework to develop and assess nanosystems that provide unique advantages in biomedical applications
Nanotechnology in Therapeutics explores the idea that by studying in depth the behavior of living organisms, especially the functionality of their cell membranes, we can develop and evaluate innovative bio-inspired nanosystems that are able to deliver small molecules, biomolecules like proteins, peptides, and other genetic material in terms of the production of new therapies and vaccines. The main concept promoted in this book is an integrated approach for producing new medicines following the nanotoxicity, biotoxicity, regulatory, and ethical guidelines, which are also covered in the book.
The book is divided into three parts. Part A provides an introduction and a historical overview of nanotechnology. Part B delves deeper into issues relating to lipid and polymeric nanostructures in medicine. Part C presents the regulatory landscape around nanotechnology and nanomedicine, while highlighting the need to keep an eye on emerging technologies such as artificial intelligence and machine learning. Overall, this book opens up biomedical applications for previously challenging drugs and drug targets.
Written by a highly qualified professor with significant pertinent research experience, Nanotechnology in Therapeutics includes discussion on: Eukaryotic cell membranes, their structural properties, and the thermodynamic payload of their lipid bilayers
The DLVO (Derjaguin, Landau, Verwey and Overbeek) theory as a scientific tool for studying the stability and the behavior of nanoparticles
Liposomes, lipid nanoparticles, and solid lipid nanoparticles, as well as polymeric nanoparticles, like micelles, polymersomes, and dendrimers
Issues in the approval process of nanomedicines by the regulatory agencies, such as complexity, chaos, and nonlinear dynamics

With comprehensive coverage of novel concepts that have the potential to transform how new medicines are designed and developed, Nanotechnology in Therapeutics is an essential resource on the subject for chemists in industry, as well as biomedical and pharmaceutical engineers.


Costas Demetzos is Professor of Pharmaceutical Nanotechnology at the National and Kapodistrian University of Athens. Currently, Prof. Demetzos serves as Director of the Laboratory of Pharmaceutical Technology, and since 2008 he serves as President of the Hellenic Pharmaceutical Society (HPS). His research interests include pharmaceutical nanotechnology, nanomedicine, and thermodynamics.
Details
Weitere ISBN/GTIN9781394274079
ProduktartE-Book
EinbandartE-Book
FormatEPUB
Verlag
Erscheinungsjahr2024
Erscheinungsdatum01.07.2024
Seiten304 Seiten
SpracheEnglisch
Dateigrösse9777
Artikel-Nr.17232322
Rubriken
Genre9201

Inhalt/Kritik

Leseprobe

List of Abbreviations
ACE2 Angiotensin-converting enzyme 2 ADME Absorption distribution metabolism and excretion aDDnS Advanced drug delivery nanosystems AFM Atomic force microscopy APC Antigen presenting cells AI Artificial intelligence AIDS Acquired immunodeficiency syndrome ANN Artificial neural network ATMP Advanced therapy medicinal product ATP Adenosine triphosphate AuNR Gold nanorod BCD Biological complex drugs CAT Committee for Advanced Therapies CBER Center for Biological Evaluations and Research CDER Center for Drug Evaluation and Research CDRH Center for Device and Radiological Health c-DOPE citraconyl-DOPE (1,2-dioleoyl-3-phosphatidylethanotamine) CHMP Committee for Medicinal Products for Human Use CLN Core-shell lipid nanoparticle CPP Critical packing parameter CRISPR Clustered regularly interspaced short palindromic repeats Cryo-AFM Cryogenic atomic force microscopy Cryo-TEM Cryo-transmission electron microscopy CQAs Critical quality attributes CVD Cardiovascular disease CVM Center for Veterinary Medicine DAPE Diacetylenic phosphatidylethanolamine ÎCpmax Change of maximum heat capacity ÎÎ Change in enthalpic content ÎT1/2 Change in transition's width at half peak height DLin-MC3-DMA (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethyl-amino)butanoate DLVO Derjaguin, Landau, Verwey, and Overbeek DL Deep learning DLS Dynamic light scattering DMA Dynamic mechanical analysis DMPC Dimyristoylphosphatidylcholine DMPG Dimyristoylphosphatidylglycerol DOPC Dioleoyl-phosphatidylcholine DOPE Dioleoyl-phosphatidylethanolamine DODMA 1,2-Dioleyloxy-3-dimethylaminopropane DOTAP 1,2-Dioleoyl-3-(trimethylammonium)-propane DOTMA N-1-(2,3-dioleoyloxy)-propyl-N,N,N-trimethylammonium DPH Diphenylhexatriene DPPC Dipalmitoyl-phosphatidylcholine DPPE Dipalmitoyl-phosphatidylethanolamine DPPG Dipalmitoyl-phosphatidylglycerol DQA Deqalinium DSPE-PEG Distearoyl-phosphatidylethanolamine-polyethylene glycol DSPC Distearoyl-phosphatidylcholine DSC Differential scanning calorimetry DT Digital therapeutic DTA Differential thermal analysis DTG Differential thermogravimetry EAPP European agency for pharmaceutical products EC European Commission EEA European Economic Area EFSA European Food Safety Authority EFTA-EEA European Free Trade Associations-European Economic Area EGA Evolved gas analysis EHF Ebola hemorrhagic fever ELS Electrophoretic light scattering EM Electronic microscopy EMA European Medicine Agency EMEA European Agency for the Evaluation of Medicinal Products EPAR European Public Assessment Report EPC Egg-phosphatidylcholine EPR Enhanced permeability and retention ETP European technology platform ETPN European technology platform on nanomedicine EU European Union EVD Ebola virus disease FDA Food and Drug Administration FFEM Freeze fracture electron microscopy FF-TEM Freeze-fracture transmission electron microscopy FTIR Fourier transform infrared spectroscopy G Gibbs free energy GDPR General data protection regulation GI Gastrointestinal GMO Glyceryl monooleate GMP Good manufacturing practice GPI Glycosylphosphatidylinositol GTMP Gene therapy medicinal product GUV Giant unilamellar liposome HHV Human herpes virus HIV Human immunodeficiency virus HLA Human leukocyte antigen HSPC Hydrogenated soy phosphatidylcholine ICH International Conference for Harmonization ICTAC International Confederation for Thermal Analysis and Calorimetry IMM Inner mitochondrial membrane IMS Intermembrane space IND Investigational new drug application ITF Innovation task force IUPAC International Union of Pure and Applied Chemistry KET Key enabling technologies LC Liquid crystal LFM Lateral force microscopy LTL Ligand-targeted liposome LNP Lipid nanoparticle LUV Large unilamellar vesicle LVEM Low voltage electron microscopy MAA Marketing authorization application MAS 13C-NMR Magic angle spinning 13C-nuclear magnetic resonance MDM Material data mining MHM Modified heating method MPEG-DSPE Methoxypolyethylene glycol-distearoyl-phosphatidylcholine MPEG 2000-DSPE Methoxypolyethylene glycol 2000-distearoyl-phosphatidylcholine MPP Mitochondria penetrating peptide MPS Mononuclear phagocyte system MRI Magnetic resonance imaging MLV Multilamellar vesicle mtDNA mitochondrial DNA MVL Multivesicular liposome MVV Multivesicular vesicle MLL Multilamellar liposomes NASBA Nucleic acid sequence-based amplification NBCD Non-biological complex drugs NCI National Cancer Institute NDA New drug application NFAS Non-flame atomic spectroscopy NHT New health technology NIR Near infrared NLC Nanostructured lipid carriers NMR Nuclear magnetic resonance NNI National nanotechnology initiative NP Nanoparticle NPLD Non-PEGylated liposome doxorubicin OLV Oligolamellar vesicle OMM Outer mitochondrial membrane OTC Over the counter PAMAM Poly(amidoamine) PC Phosphatidylcholine PCR Polymerase chain reaction PCS Photon correlation spectroscopy PDI Polydispersity index PDT Photodynamic therapy PE Phosphatidylethanolamine PEO Polyethylene oxide PEO-PMPS Poly(ethylene oxide)-poly(methylphenylsilane) PET Positron emission tomography PEG Polyethylene glycol PEG-DMG Polyethyleneglycol-dimyristoyl glycerol PLGA Poly(lactic-co-glycolic acid) PNP Polymeric nanoparticles PPP Public-private partnership PPI Protein-protein interaction PRIME Priority medicines program QSAR/QSPR Quantitative structure-activity/property relationship RAS protein Rat sarcoma virus protein RBD Receptor binding domain REM Reflection electron microscopy RES Reticuloendothelial system ROS Reactive oxygen species RT-PCR Reverse transcription polymerase chain reaction sCTMP Somatic cell therapy medicinal...
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