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Mouse Models of Human Blood Cancers

Basic Research and Pre-clinical Applications - Previously published in hardcover
BuchKartoniert, Paperback
293 Seiten
Englisch
Springererschienen am19.09.20142008
In this book, Dr. Li and his author team plan to emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The authors do not intend to cover all types of blood cancers; instead, they will focus on some major ones such as leukemias and lymphomas. However, the authors will try to cover as much as they can the cancer types and point out that many blood cancers need to be studied in mouse disease models although they are still not available at present. A major focus in the book will be to show what we can or cannot learn from mouse disease models and to also show the critical contributions of mouse models in therapeutic drug development.mehr
Verfügbare Formate
BuchKartoniert, Paperback
EUR160,49
BuchGebunden
EUR160,49

Produkt

KlappentextIn this book, Dr. Li and his author team plan to emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The authors do not intend to cover all types of blood cancers; instead, they will focus on some major ones such as leukemias and lymphomas. However, the authors will try to cover as much as they can the cancer types and point out that many blood cancers need to be studied in mouse disease models although they are still not available at present. A major focus in the book will be to show what we can or cannot learn from mouse disease models and to also show the critical contributions of mouse models in therapeutic drug development.
ZusammenfassungDr. Li and his Jackson Laboratory team emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The Jackson Laboratory is the world's largest mouse genetics institution.
Details
ISBN/GTIN978-1-4899-8665-8
ProduktartBuch
EinbandartKartoniert, Paperback
Verlag
Erscheinungsjahr2014
Erscheinungsdatum19.09.2014
Auflage2008
Seiten293 Seiten
SpracheEnglisch
Gewicht492 g
IllustrationenX, 293 p.
Artikel-Nr.32977177
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
Chapter 1 Mouse models of myeloproliferative disease associated with mutant JAK2 tyrosine kinase: insights into pathophysiology and therapy Richard A. Van Etten Chapter 2 Genetic modeling of human blood cancers in mice Yiguo Hu and Shaoguang Li Chapter 3 Murine Models of Hematopoietic Disease: Pathologic Analysis and Characterization Benjamin H Lee and Jeffery L. Kutok Chapter 4 Mechanisms of DNA double strand break repair in hematopoietic homeostasis and oncogenesis Sarah A. Maas, Lura Brianna Caddle, and Kevin D. Mills Chapter 5 Modeling human leukemia using immune-compromised mice F Ishikawa, Y Saito, and LD Shultz Chapter 6 Dietary Restriction: A model system probing the cell fate decision between cancer and senescence Robin P. Ertl and David E. Harrison Chapter 7 Modeling human Philadelphia chromosome-positive leukemia in mice Shaoguang Li Chapter 8 Mouse Models of Human Mature B Cell and Plasma Cell Neoplasms Siegfried Janz, Herbert C. Morse III, and Michael A. Teitell Chapter 9 Genetic and Virological Predisposition to Pre-B Lymphomagenesis in SL/Kh Hiroshi Hiai Chapter 10 Animal cancer models in anticancer drug discovery and development Francis Lee and Roberto Weinmann Bristol-Myers Squibb Oncology, Princeton, New Jersey, USA Chapter 11 DGL Global Strategies in DNA Microarray Gene Expression Analysis and Data Mining forHuman Blood Cancers Dongguang Limehr