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Tumor Suppressor Par-4

Structural Features, Molecular Mechanisms and Function
BuchGebunden
323 Seiten
Englisch
Springererschienen am09.01.20221st ed. 2022
Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar´s laboratory in prostate cancer cells undergoing apoptosis.mehr
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Produkt

KlappentextPar-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar´s laboratory in prostate cancer cells undergoing apoptosis.
Details
ISBN/GTIN978-3-030-73571-5
ProduktartBuch
EinbandartGebunden
Verlag
Erscheinungsjahr2022
Erscheinungsdatum09.01.2022
Auflage1st ed. 2022
Seiten323 Seiten
SpracheEnglisch
IllustrationenX, 323 p. 84 illus., 81 illus. in color.
Artikel-Nr.16382926
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
IntroductionChapter 1. Discovery and Overview of Par-4Chapter 2. Significance of Par-4 Interaction with aPKCChapter 3. Structural Analysis of the C-terminal domain of Par-4Chapter 4. Crystallization and crystallographic analysis of the C-terminal domain of Par-4 (PAWR)Chapter 5. Role of ubiquitinase FBX045 in Par-4 regulationChapter 6. Regulation of Par-4 by type II phosphatidylinositol 4-kinase Î²Chapter 7. Role of Par-4 in regulation of cell death by circumin and ceramideChapter 8. Par-4 in dissociation induced cell death in human pluripotent stem cellsChapter 9. Role of Par-4 in EMTChapter 10. Bacillus thuringiensis Induced Par-4 and Apoptosis in Human CellsChapter 11. Role of Par-4 in ZebrafishChapter 12. Role of Par-4 in GRP78 translocationChapter 13. Interaction of THAP1 with Par-4 in PML bodiesChapter 14. Regulation of DAPK and AMIDA by Par-4Chapter 15. Regulation of Par-4 by CK2 kinasemehr

Autor

Vivek M. Rangnekar, Ph.D. is Professor and Alfred Cohen Chair in Oncology Research in the Department of Radiation Medicine and Associate Director of the Markey Cancer Center at the University of Kentucky. His laboratory studies the molecular cross-talk between oncogenes and tumor suppressor genes in an effort to tilt the balance in favor of tumor suppressor function. Dr. Rangnekar originally discovered and identified the tumor suppressor protein Par-4/PAWR in 1993.
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Herausgegeben:Rangnekar, Vivek M.