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BuchGebunden
710 Seiten
Englisch
Springererschienen am09.11.20221st ed. 2022
This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics.mehr
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BuchGebunden
EUR213,99
BuchKartoniert, Paperback
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BuchGebunden
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BuchKartoniert, Paperback
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Produkt

KlappentextThis book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics.
Details
ISBN/GTIN978-3-031-08880-3
ProduktartBuch
EinbandartGebunden
Verlag
Erscheinungsjahr2022
Erscheinungsdatum09.11.2022
Auflage1st ed. 2022
Seiten710 Seiten
SpracheEnglisch
IllustrationenIX, 710 p. 93 illus., 82 illus. in color.
Artikel-Nr.16553167

Inhalt/Kritik

Inhaltsverzeichnis
Preface: History of VGCCs                                                                                           STRUCTURAL AND MOLECULAR ASPECTS OF VGCCS1.       Measuring and manipulating calcium2.       Structure, function and subunit assembly of VGCC3.       Splice variation and RNA editing of VGCCs4.       Mechanisms of calcium channel permeation5.       Regulation by beta subunits       6.       Regulation by alpha2 delta subunits7.       VGCCs in invertebratesREGULATION OF VGCCS8.       Modulation by GPCRs and second messengers9.       Trafficking of VGCCs10.   Calcium regulation11.   Calcium channel complexes with other channels12.   Regulation of gene transcription by VGCCs (PATHO)PHYSIOLOGY OF VGCCS13.   Lessons from knock-out and knock-in mice14.   VGCCs and synaptic transmission15.   Cardiovascular syste16.   Calcium channels and exocytosis in chromaffin cells17.   Calcium channels in the pancreas in health and disease18.   Skeletal muscle system19.   Auditory and visual systems20.   Calcium channels and pain transmission21.   Migraine22.   Epilepsy23.   Psychiatric disorders24.   Parkinson´s disease25.   Reproductive system26.   CancerPHARMACOLOGY OF VGCCS27.   Molecular determinants of VGCC pharmacology28.   Interactions with peptide toxins29.   Clinical pharmacology and drug discoverymehr

Schlagworte

Autor

Dr. Gerald Werner Zamponi is a Professor in the Department of Physiology and Biophysics, and Canada Research Chair in Molecular Neuroscience, at the University of Calgary, Calgary, Canada.



Dr. Norbert Weiss is an Assistant Professor in the Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
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Herausgegeben:Zamponi, Gerald Werner