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BuchKartoniert, Paperback
298 Seiten
Englisch
Springererschienen am23.10.2012Softcover reprint of the original 1st ed. 2001
In step with our growing lifespan, dementia is becoming a widespread handicap to the health and well-being of individuals and a burden on human society world-wide.mehr
Verfügbare Formate
BuchGebunden
EUR85,55
BuchKartoniert, Paperback
EUR53,49
E-BookPDF1 - PDF WatermarkE-Book
EUR53,49

Produkt

KlappentextIn step with our growing lifespan, dementia is becoming a widespread handicap to the health and well-being of individuals and a burden on human society world-wide.
Details
ISBN/GTIN978-3-0348-9482-1
ProduktartBuch
EinbandartKartoniert, Paperback
Verlag
Erscheinungsjahr2012
Erscheinungsdatum23.10.2012
AuflageSoftcover reprint of the original 1st ed. 2001
Seiten298 Seiten
SpracheEnglisch
Gewicht498 g
IllustrationenXXI, 298 p.
Artikel-Nr.29577370
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
Special lectures.- A tale of protein kinase C and membrane lipid signaling.- Complement, neuroinflammation and neuronal degeneration in Alzheimer disease.- Memory and its impairment.- Neurobiological mechanisms by which emotional arousal influences long-term memory formation.- Amygdalar damage and memory impairment in Alzheimer´s disease.- Neural substrate for spatial memory in the monkey hippocampus.- Involvement of CaM kinase II and mitogen-activated protein kinase in hippocampal long-term potentiation.- Pathogenesis of dementia - tau.- Transgenic mice overexpressing the shortest human tau isoform develop a progressive tauopathy.- Tau and neurodegenerative disease: genetics and pathogenetic mechanisms.- Tau mutations altering splicing of tau exon 10 in japanese frontotemporal dementia.- Amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula of Japan (Kii ALS/PDC) may be a familial tauopathy. Epidemiological trends, clinical features, neuropathology and molecular genetics.- Senile dementia of the neurofibrillary tangle type (SD-NFT): a clinical, neuropathological and molecular genetic study.- The dual role of tau in cell polarisation and organelle trafficking.- Rearrangement of microtubule networks by tau bearing missense mutations.- Possible role of tau phosphorylation on ER membrane in Alzheimer pathology.- Pathogenesis of dementia - synuclein.- Pathogenesis of dementia: updating the role of synuclein pathology in sporadic and hereditary Alzheimer´s disease.- ?-Synuclein/NACP and neurodegeneration.- ?-Synuclein fibrillogenesis as target for drug development.- Pathogenesis of dementia - presenilin and amyloid.- Genetics of early-onset Alzheimer disease.- Lessons from presenilin domain analysis: endoproteolytic processing andenhanced A?42 production mediated by FAD-linked variants.- Amyloid and presenilins in the pathobiology of Alzheimer´s disease.- Role of presenilin in APP processing and A? production.- Impairment of response to ER stress in presenilin 1 mutant.- Mechanism of neuron death in Alzheimer´s disease.- Notch3 gene in CADASIL syndrome: mutation frequencies in Japanese and its expression and processing.- Etiological roles of A? and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease.- Amyloid ?-protein granules in glial cells in Alzheimer´s disease brain.- Amyloid ? induces phosphorylation and translocation of MARCKS through tyrosine kinase-activated PKC-? signaling pathway in microglia.- Amyloid ?-protein accumulation in the human brain during aging.- Molecular mechanisms underlying initiation of amyloid fibril formation.- Catabolism of amyloid-? peptide in brain parenchyma.- Diagnosis and therapeutics of dementia.- Lessons in familial Alzheimer´s disease.- Biological markers for differential diagnosis of Alzheimer´s disease and related disorders.- Dietary factors and the risk of Alzheimer´s disease: a low fish consumption and a relative deficiency of ?-3 polyunsaturated fatty acids.- Risk factors for dementia.- New therapeutic approaches to Alzheimer´s disease.mehr