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DNA-Encoded Libraries

Hardback (Thread Stitching)
BuchGebunden
716 Seiten
Englisch
Thiemeerscheint am23.09.2024
Techniques and methods employed in the preparation and application of DNA-Encoded Libraries.DNA Encoded Libraries (DELs) have transformed the way we explore chemical space, accelerating drug discovery and innovation. This volume contains a collection of articles, bringing together many of the leaders in the field, from both industry and academia, to explore the cutting-edge techniques, strategies, and applications that are reshaping the landscape of chemical synthesis.The volume covers many aspects of this rapidly expanding field, from DNA-compatible organic reactions to innovative encoding methods and setup strategies, selection procedures, and advanced chemoinformatic techniques.Whilst background information is provided, the focus of the articles is on the techniques and methods: experts in the field present selected procedures, showing the state of the art in each area covered.This volume is an indispensable resource for chemists, researchers, and professionals seeking to stay at the forefront of chemical synthesis and drug discovery.mehr
Verfügbare Formate
BuchGebunden
EUR2.999,99
E-BookPDF1 - PDF WatermarkE-Book
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Produkt

KlappentextTechniques and methods employed in the preparation and application of DNA-Encoded Libraries.DNA Encoded Libraries (DELs) have transformed the way we explore chemical space, accelerating drug discovery and innovation. This volume contains a collection of articles, bringing together many of the leaders in the field, from both industry and academia, to explore the cutting-edge techniques, strategies, and applications that are reshaping the landscape of chemical synthesis.The volume covers many aspects of this rapidly expanding field, from DNA-compatible organic reactions to innovative encoding methods and setup strategies, selection procedures, and advanced chemoinformatic techniques.Whilst background information is provided, the focus of the articles is on the techniques and methods: experts in the field present selected procedures, showing the state of the art in each area covered.This volume is an indispensable resource for chemists, researchers, and professionals seeking to stay at the forefront of chemical synthesis and drug discovery.
Details
ISBN/GTIN978-3-13-245522-1
ProduktartBuch
EinbandartGebunden
Verlag
Erscheinungsjahr2024
Erscheinungsdatum23.09.2024
Seiten716 Seiten
SpracheEnglisch
Gewicht1477 g
Artikel-Nr.55905753

Inhalt/Kritik

Inhaltsverzeichnis
1 Introduction2 DNA-Compatible Organic Reactions2.1 Amide-Bond-Forming Reactions2.2 Metal-Promoted DEL-Compatible C-C Bond Forming Reactions2.3 Metal-Free DEL-Compatible C-C Bond Forming Reactions2.4 On-DNA C-X (X = N, O, P, S, Se) Bond Forming Reactions2.5 On-DNA C-H Transformations2.6 On-DNA Photoredox-Catalyzed Reactions2.7 On-DNA Cyclization Reactions2.8 DNA-Encoded Isocyanide Multicomponent Reactions2.9 On-DNA Functional-Group Transformations2.10 Reversible Immobilization of DNA for Chemical Modification2.11 Covalent Attachment on a Solid Support2.12 Micelle-Mediated Synthesis3 DEL Encoding and Setup Strategies3.1 DNA-Templated Synthesis3.2 DNA-Recorded Synthesis3.2.1 Single Pharmacophore Libraries3.2.1.1 Encoding Using Double-Stranded DNA: A Headpiece-Based DNA Ligation Strategy3.2.1.2 Encoding Using Single-Stranded DNA (Iterative Splint-Ligation Procedures)3.2.1.3 Chemical Ligation/Encoding3.2.2 Dual-Pharmacophore Libraries3.2.2.1 Encoded Self-Assembling (Dynamic) Chemical Libraries3.2.2.2 Peptide Nucleic Acid (PNA) Encoded Libraries3.2.2.3 DNA-Encoded Dynamic Combinatorial Chemical Libraries3.2.3 Special Libraries3.2.3.1 Macrocyclic DELs3.2.3.2 Natural-Product-Enriched DELs4 Library Selection Procedures4.1 Selections by Affinity Capture on Solid Support4.2 DEL Selection Using DNA-Programmed Affinity Labelling (DPAL)4.3 Selections of DNA-Encoded Libraries to Protein Targets on Living Cells4.4 Selections of DNA-Encoded Libraries to Protein Targets within Living Cells5 Evaluation/Cheminformatic Methods5.1 Informatic Tools, Processing, and Evaluation of DEL Selection Data5.2 On-DNA Resynthesis and Affinity Selection Mass Spectrometry (ASMS)mehr