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Radiobiology of Glioblastoma

Recent Advances and Related Pathobiology
BuchGebunden
305 Seiten
Englisch
Springererschienen am16.06.20161st ed. 2016
This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain.mehr
Verfügbare Formate
BuchGebunden
EUR106,99
BuchKartoniert, Paperback
EUR106,99
E-BookPDF1 - PDF WatermarkE-Book
EUR53,49

Produkt

KlappentextThis text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain.
Details
ISBN/GTIN978-3-319-28303-6
ProduktartBuch
EinbandartGebunden
Verlag
Erscheinungsjahr2016
Erscheinungsdatum16.06.2016
Auflage1st ed. 2016
Seiten305 Seiten
SpracheEnglisch
Gewicht819 g
IllustrationenXX, 305 p. 49 illus., 39 illus. in color.
Artikel-Nr.36273939
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
Introduction and Background.- The Radio-resistance of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options.- Radiobiological Hints from Clinical Studies.- Chemo-radiotherapy: Radiation Total Dose and Fractionation.- Clinical Evidence and Radiobiological Background of Particle Radiation Therapy.- Mathematical Modeling of Radiobiological Parameters from Clinical Studies.- Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series.- Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond.- Basic Knowledge of Glioblastoma Radiobiology.- Molecular Radiobiology and Mathematical Modeling.- Genetic and Epigenetic Determinants in Tumor Initiation and Progression.- Tumor Microenvironment.- Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy.- mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models.- Glioma Stem-like Cells and Radiation Resistance.- Hypoxia and Radiation Resistance.- Invasiveness and Radiation Failures.- Nanoparticle Technology for Research Radiobiology.- The Molecular Classification of Glioblastoma as a Translational Instrument.- Translational Perspectives for Gene Therapy.- Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods.- From Molecular to Clinical Radiation Biology.- Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results.- Conclusive Remarks and Perspectives for Future Research.mehr
Kritik
"This is a very detailed monograph on the roles of radiation, immunotherapy, genetic, epigenetic, and chemotherapy in the treatment of Glioblastoma. Biomarkers and molecular mechanisms of GBMs are discussed. ... I highly recommend this book to oncologists, neurosurgeons, neurologists, and researchers involved in this perplexing baffling tumor." (Joseph Grenier, Amazon.com, May, 2018)mehr

Autor

Dr. Luigi PirtoliRadiation Oncology UnitDepartment of Medicine, Surgery and NeurosciencesUniversity of SienaSiena, Italy
Dr. Giovanni Luca GravinaDepartment of Biology and BiotechnologyUniversity of PaviaRome, Italy
Antonio GiordanoSbarro Institute for Cancer Research and Molecular Medicine and Center for BiotechnologyTemple UniversityPhiladelphia, PA, USADepartment of Medicine, Surgery & NeurosciencesUniversity of SienaSiena, Italy
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Herausgegeben:Pirtoli, Luigi
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