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Mitochondrial Dysfunction in Neurodegenerative Disorders

BuchGebunden
380 Seiten
Englisch
Springererschienen am21.06.20162. Aufl.
This second edition brings together up-to-date contributionsfrom leaders in the field internationally on the various ways in whichmitochondrial dysfunction contributes to the pathogenesis of neurodegenerativediseases, including Parkinson´s disease, Alzheimer´s disease and multiplesclerosis.mehr
Verfügbare Formate
BuchGebunden
EUR106,99
BuchKartoniert, Paperback
EUR144,44
E-BookPDF1 - PDF WatermarkE-Book
EUR96,29

Produkt

KlappentextThis second edition brings together up-to-date contributionsfrom leaders in the field internationally on the various ways in whichmitochondrial dysfunction contributes to the pathogenesis of neurodegenerativediseases, including Parkinson´s disease, Alzheimer´s disease and multiplesclerosis.
Zusammenfassung
Discusses current research in a concise and logical format

Explains concepts using schematic diagrams, images and tables

Covers all aspects of the potential contribution of mitochondria

to neurodegenerative diseases, from the simple to the more complex, both in

terms of experimental data and literature review
Details
ISBN/GTIN978-3-319-28635-8
ProduktartBuch
EinbandartGebunden
Verlag
Erscheinungsjahr2016
Erscheinungsdatum21.06.2016
Auflage2. Aufl.
Seiten380 Seiten
SpracheEnglisch
Gewicht767 g
IllustrationenXI, 380 p. 34 illus., 29 illus. in color.
Artikel-Nr.36273859
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
Part I.Mitochondria and Neurodegenerative Disease.- An Introductionto Mitochondria, Their Structure and Functions.- Part II.Mitochondrial Dysfunction: Causes and Effects?.- Neurodegeneration in Mitochondrial Disorders.- The Ageing Brain,Mitochondria and Neurodegeneration.- Mitochondrial Genes and Neurodegenerative Disease.- MitochondrialSignalling and Neurodegeneration.- Part III. Functional Consequences ofMitochondrial Dysfunction.- Life on the Edge: Determinants of SelectiveNeuronal Vulnerability in Parkinson´s Disease.- MitochondrialDynamics and Neurodegeneration.- Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation.-Mitochondria,the Synapse, and Neurodegeneration.- Protein Misfolding andAggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration.-Mitochondrial Degradation, Autophagy andNeurodegenerative Disease.- The DeleteriousDuo of Neurodegeneration: Lysosomes and Mitochondria.- PartIV. Measuring theContribution of Mitochondrial Dysfunction to Neurodegenerative Disease.- CanWe Accurately Model Mitochondrial Dysfunction in Neurodegeneration?.- MitochondrialFunction and Dynamics Imaged In Vivo.-Part V.  The Future.- Developmentof Treatments and Therapies to Target Mitochondrial Dysfunction.- Summary and Conclusions.mehr

Autor

Amy K. Reeve

Amy did her undergraduate degreein Neuroscience at Edinburgh University before moving to the MitochondrialResearch Group at Newcastle University for her PhD studies. She completed her PhDin the study of the molecular mechanisms of neurodegenerative disease in 2007and now has her own research group within the Wellcome Trust Centre forMitochondrial Research. Her current research interests centre aroundunderstanding the mechanisms behind the neurodegeneration seen in Parkinson'sdisease, and the contribution of mitochondrial dysfunction to these changes.Funded by Parkinson's UK as a research fellow Amy's interests lie inunderstanding how changes within mitochondria, mitochondrial transport and theinteraction of mitochondrial with alpha-synuclein contributes to thedevelopment of Parkinson's disease.
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