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Hereditary Colorectal Cancer

Genetic Basis and Clinical Implications
BuchGebunden
505 Seiten
Englisch
Springererschienen am18.05.20181st ed. 2018
This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention.mehr
Verfügbare Formate
BuchGebunden
EUR213,99
BuchKartoniert, Paperback
EUR165,84
E-BookPDF1 - PDF WatermarkE-Book
EUR160,49

Produkt

KlappentextThis book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention.
Zusammenfassung
Comprehensive and updated coverage of the topic

Novel findings and challenges discussed

Provides coverage of issues ranging from genetics to clinical description of the syndromes
Details
ISBN/GTIN978-3-319-74258-8
ProduktartBuch
EinbandartGebunden
Verlag
Erscheinungsjahr2018
Erscheinungsdatum18.05.2018
Auflage1st ed. 2018
Seiten505 Seiten
SpracheEnglisch
Gewicht930 g
IllustrationenX, 505 p. 53 illus., 39 illus. in color.
Artikel-Nr.44282952
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
Part1 : GENETIC CAUSES AND ASSOCIATED PHENOTYPES- Lynch syndrome.- The molecular basis of Lynch-like syndrome.- Constitutional mismatch repair deficiency.- Mismatch repair proficient hereditary non-polyposis colorectal cancer.- Genetic and environmental modifiers of risk in Lynch syndrome.- ADENOMATOUS POLYPOSIS SYNDROMES- Introduction.- Familial adenomatous polyposis.- Polymerase proofreading-associated polyposis.- MUTYH-associated polyposis.- NTHL1-associated polyposis.- Germline biallelic inactivation of MMR genes (with polyposis phenotype).- Unexplained adenomatous polyposis.- HAMARTOMATOUS POLYPOSIS SYNDROMES- Peutz-Jeghers syndrome.- Juvenile polyposis syndrome.- PTEN-hamartoma tumor syndromes.- Other hamartomatous polyposis conditions.- HEREDITARY MIXED POLYPOSIS SYNDROME.- SERRATED POLYPOSIS SYNDROME.- Part2: GENETIC DIAGNOSTICS  and CLINICAL MANAGEMENT.- Genetic testing in hereditary colorectal cancer.- Universal tumor screening for Lynch syndrome.- Classification of genetic variants. Prediction models for Lynch syndrome.- Surveillance guidelines for hereditary colorectal cancer syndromes.- Surgical management of hereditary colorectal cancer syndromes.- Chemoprevention in hereditary colorectal cancer syndromes.- Immunotherapy in hereditary colorectal cancer.- The Immune Biology of Microsatellite Unstable cancer.- Hereditary colorectal cancer: Immunotherapy approaches.- Medical oncology management of hereditary colorectal cancer. Part3: REGISTRIES and DATABASES.- Databases: intentions, capabilities and limitations.- The Colon Cancer Family Registry Cohort.- The Prospective Lynch Syndrome Database.- The InSiGHT Database: An example LOVD system.- The International Mismatch Repair Consortium.mehr
Kritik
"This unique book is designed as a consultative source for individuals involved in the care of patients with colorectal cancer and patients at risk due to familial genetic testing. ... Genetics counselors, medical geneticists, surgeons, and oncology specialists would find this book extremely useful. ... One of the most impressive features of this book is the very useful abstract at the beginning of every chapter. ... At the end, there is a section of registries and databases, extremely useful tools." (Luis F. Escobar, Doody's Book Reviews, October, 2018)mehr

Autor

Laura Valle, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Av. Gran Via 199-203, 08908Barcelona, SpainProf. Dr. Stephen Gruber, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, 90033, USADr. Gabriel Capella, Institut Català d'Oncologia (ICO), Av. de la Granvia de l'Hospitalet 199, 08907 Barcelona, Spain
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