Acute Myelogenous Leukemia in Childhood

Implications of Therapy Studies for Future Risk-Adapted Treatment Strategies

von

Herausgegeben von Creutzig, UrsulaRitter, JörgSchellong, Günther

BuchKartoniert, Paperback

163 Seiten

Englisch

Springererschienen am05.10.1990

Another result of the BFM-83 study was the definition of two risk groups on the basis of standardized treatment, which has lead to a risk-adapted treatment strategy in the third ongoing trial, AML-BFM- 87. Munster, April 1990 Ursula Creutzig Jorg Ritter Gunther Schellong Contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . 1 .mehr

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KlappentextAnother result of the BFM-83 study was the definition of two risk groups on the basis of standardized treatment, which has lead to a risk-adapted treatment strategy in the third ongoing trial, AML-BFM- 87. Munster, April 1990 Ursula Creutzig Jorg Ritter Gunther Schellong Contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . 1 .

Details

ISBN/GTIN978-3-540-52070-2

ProduktartBuch

EinbandartKartoniert, Paperback

Verlag

Springer

Erscheinungsjahr1990

Erscheinungsdatum05.10.1990

Seiten163 Seiten

SpracheEnglisch

Gewicht360 g

IllustrationenXVI, 163 p. 3 illus.

Artikel-Nr.18220519

Rubriken

GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis

1 Introduction.- 1.1 Development of AML Therapy in Children.- 1.2 Prognostic Parameters in AML.- 1.3 Objectives of the Analysis.- 2 Patients and Therapy.- 2.1 Patient Eligibility.- 2.2 Therapy Schedule for Study AML-BFM-78.- 2.3 Therapy Schedule for Study AML-BFM-83.- 3 Definitions and Methods.- 3.1 Definitions.- 3.2 Diagnostic Methods.- 3.3 Statistical Methods.- 4 Results.- 4.1 Analysis of Pretherapeutic Patient Data.- 4.2 Correlation of Initial Parameters Including Kinetics of Blast Cell Reduction.- 4.3 Outcome.- 4.4 Results by Morphologic Subtypes.- 4.6 Early Death Due to Hemorrhage and/or Leukostasis and Other Complications.- 4.7 Analysis of the Implementation of Therapy in AML-BFM-83 Study.- 4.8 Toxicity During the Individual Therapy Phases of AML-BFM-83 Study.- 5 Discussion.- 5.1 Clinical and Morphologic Characteristics of Childhood AML.- 5.1.1 Epidemiological Factors.- 5.1.2 Clinical Data.- 5.2 Characterization of the FAB Types M1-M7 in Children by Pretherapeutic Parameters.- 5.3 Evaluation of the Relationship Between Pretherapeutic Parameters.- 5.4 Prognostic Relevance of Pretherapeutic Parameters and Response Kinetics: Definition of Prognostic Groups.- 5.5 Influence of Therapy on the Prognostic Relevance of Pretherapeutic Parameters: Evaluating the Introduction of ADE Induction Therapy in AML-BFM-83 Study.- 5.6 Early Death Due to Hemorrhage and/or Leukostasis and Other Complications: Consequences for Initial Therapy.- 5.7 Relationship Between Implementation of Therapy, Complications, and Course.- 5.8 Perspectives for Future Prognosis-Adapted Therapy Strategies.- 6 Summary.- 7 References.- 8 Appendix.- 9 Subject Index.mehr