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Drug Design

Methodology, Concepts, and Mode-of-Action
BuchGebunden
901 Seiten
Englisch
Springererschienen am10.07.2013
Unique work on structure-based drug design, covering multiple aspects of drug discovery and development.mehr

Produkt

KlappentextUnique work on structure-based drug design, covering multiple aspects of drug discovery and development.
Zusammenfassung
Unique reference work on the subject of drug design

Full colours throughout

Intelligibly written and illustrated containing over 100 computer graphics

Including an index of about 5,000 items
Details
ISBN/GTIN978-3-642-17906-8
ProduktartBuch
EinbandartGebunden
Verlag
Erscheinungsjahr2013
Erscheinungsdatum10.07.2013
Seiten901 Seiten
SpracheEnglisch
Gewicht1532 g
IllustrationenXV, 901 p. 496 illus., 333 illus. in color.
Artikel-Nr.11712175
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
Part I  Fundamentalsin Drug Research.- 1. Drug Research Yesterday, Today and Tomorrow.- 2. The Role of Serendipityin Drug Research.- 3. Classical Drug Research.- 4. Protein-Ligand Interactionsas the Basis for Drug Action.- 5. Optical Activity and Biological Effects.- Part II Discovery and Optimizationof Lead Compounds.-  6. Screeningfor Lead Structures.- 7.  Screening Technologies for LeadDiscovery.- 8. Optimizationof Lead Structures.- 9. Designingprodrugs.- 10. Peptidomimetics.- Part III  Experimental and Theoretical Methods.- 11. Combinatorics: Chemistry With Big Numbers.- 12. Gene Technology in drug research.-  13. Experimental Methods of Structure Determination.- 14. The Spatial Structure of Biomolecules.- 15. Molecular Modelling.- 16. Conformational Analysis.- Part IV Structure-Activity Relationships and Design Approaches.- 17.Pharmacophore Hypothesis and Molecular Comparisons.- 18. Quantitative Structure-ActivityRelationships.- 19.  From in vitro to in vivo:Optimization of ADME-Tox Properties.- 20. ProteinModeling and Structure-BasedDrug Design.- 21.  ACase Study: Structure-Based Inhibtor Design for tRNA-Guanine Transglycosylase.- Part V. Drugs and drug action: Successes of stucture-based design.- 22. Howdrugs act: Concepts for therapy.- 23. Inhibitors of hydrolases With an acyl-enzymeintermediate.- 24. Asparticprotease inhibitors.- 25. Inhibitorsof hydrolysing metalloenzymes.- 26. Inhibitorsof transferases.- 27. Inhibitors ofoxidoreductases.- 28.  Agonists and antagonistsof nuclear receptors.- 29. Agonists and antagonists of membrane-bound.- 30. Ligands forchannels, pores and transporters.- 31. Ligands for surfacereceptors.- 32. Biologicals: Peptides, proteins, nucleotidesand macrolides as drugs.mehr
Kritik

Schlagworte