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Recent Advances in Transthyretin Evolution, Structure and Biological Functions

Previously published in hardcover
BuchKartoniert, Paperback
362 Seiten
Englisch
Springererschienen am05.11.20142009
Since its ?rst description in 1942 in both serum and cerebrospinal ?uid, transthyretin (TTR) has had an eventful history, including changes in name from prealbumin to thyroxine-binding prealbumin to transthyretin as knowledge increased about its functions.mehr
Verfügbare Formate
BuchGebunden
EUR246,09
BuchKartoniert, Paperback
EUR246,09

Produkt

KlappentextSince its ?rst description in 1942 in both serum and cerebrospinal ?uid, transthyretin (TTR) has had an eventful history, including changes in name from prealbumin to thyroxine-binding prealbumin to transthyretin as knowledge increased about its functions.
ZusammenfassungThe evolution of transthyretin has been extensively investigated, and while the structure of the protein has not changed, its function has changed significantly. This monograph will bring the reader up to date on the latest developments and discoveries.
Details
ISBN/GTIN978-3-642-42071-9
ProduktartBuch
EinbandartKartoniert, Paperback
Verlag
Erscheinungsjahr2014
Erscheinungsdatum05.11.2014
Auflage2009
Seiten362 Seiten
SpracheEnglisch
Gewicht581 g
IllustrationenXIII, 362 p.
Artikel-Nr.33433913
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
Mechanisms of Molecular Recognition: Structural Characteristics of Transthyretin Ligand Interactions.- Transthyretin Synthesis During Development and Evolution: What the Marsupials Revealed.- Evolution of Transthyretin Gene Structure.- Evolutionary Insights from Fish Transthyretin.- The Salmonella sp. TLP: A Periplasmic 5-Hydroxyisourate Hydrolase.- Vertebrate 5-Hydroxyisourate Hydrolase Identification, Function, Structure, and Evolutionary Relationship with Transthyretin.- Transthyretin-Related and Transthyretin-like Proteins.- The Transthyretin-Retinol-Binding Protein Complex.- Transthyretin and Retinol-Binding Protein: Implications in Fish Physiology.- Transthyretin and Endocrine Disruptors.- Genetics: Clinical Implications of Transthyretin Amyloidosis.- Molecular Pathogenesis Associated with Familial Amyloidotic Polyneuropathy.- Histidine 31: The Achilles' Heel of Human Transthyretin. Microheterogeneity is Not Enough to Understand the Molecular Causes of Amyloidogenicity.- New Therapeutic Approaches for Familial Amyloidotic Polyneuropathy (FAP).- Liver Transplantation for Transthyretin Amyloidosis.- Mouse Models of Transthyretin Amyloidosis.- What Have We Learned from Transthyretin-Null Mice: Novel Functions for Transthyretin?.- Transthyretin Null Mice: Developmental Phenotypes.- Transthyretin Null Mice as a Model to Study the Involvement of Transthyretin in Neurobiology: From Neuropeptide Processing to Nerve Regeneration.- Plasma Transthyretin Reflects the Fluctuations of Lean Body Mass in Health and Disease.- Erratum to.mehr