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Mediators and Drugs in Gastrointestinal Motility I

Morphological Basis and Neurophysiological Control
BuchKartoniert, Paperback
470 Seiten
Englisch
Springererschienen am23.11.2011Softcover reprint of the original 1st ed. 1982
Moreover, the possibility ofnew studies ofthe endocrine cells in biopsies of human intestinal mucosa even during routine endoscopies, has opened new horizons for gastroenterologists and generated a number of important contribu­ tions to our knowledge of the morphology and physiopathology of the gut.mehr

Produkt

KlappentextMoreover, the possibility ofnew studies ofthe endocrine cells in biopsies of human intestinal mucosa even during routine endoscopies, has opened new horizons for gastroenterologists and generated a number of important contribu­ tions to our knowledge of the morphology and physiopathology of the gut.
Zusammenfassung
Details
ISBN/GTIN978-3-642-68439-5
ProduktartBuch
EinbandartKartoniert, Paperback
Verlag
Erscheinungsjahr2011
Erscheinungsdatum23.11.2011
AuflageSoftcover reprint of the original 1st ed. 1982
ReiheHandbook of Experimental Pharmacology
Seiten470 Seiten
SpracheEnglisch
Gewicht846 g
IllustrationenXX, 470 p.
Artikel-Nr.18231783
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
1 Historical Perspective.- 2 Morphological Basis of Gastrointestinal Motility: Structure and Innervation of Gastrointestinal Tract.- A. Introduction.- B. Structure of Smooth Muscle.- C. Innervation of Gastrointestinal Smooth Muscle.- D. Integration of Extrinsic and Intrinsic Neurons into Reflex Circuits.- E. Conclusions.- References.- 3 Morphological Basis of Gastrointestinal Motility: Ultrastructure and Histochemistry of Endocrine-Paracrine Cells in the Gut.- A. General Cytology and Physiology.- B. Classification and Description of Cell Types.- C. Pathology.- D. Summary.- References.- 4 Ionic Basis of Smooth Muscle Action Potentials.- A. Introduction.- B. Methodologic Problems.- C. Effects of Na Ions.- D. Effects of Tetrodotoxin.- E. Na-Dependent Activity in Ca-Free Solution.- F. Effects of Ca Ions.- G. Regulation of Intracellular Ca.- H. Effects of Intracellular Ca.- I. Effects of Decreasing K Conductance.- K. Effects of Membrane Polarization.- L. Effects of Ca Antagonists.- M. General Properties of Spikes and Their Implications.- N. Summary.- References.- 5 Electrophysiology of Intestinal Smooth Muscle.- A. Introduction.- B. Methods Used In Electrical Recording.- C. Electrical Activity of Gastrointestinal Smooth Muscle.- D. Relationship Between Electrical and Mechanical Activity.- E. Migrating Myoelectric Complex.- F. Electromyography in Clinical Practice.- References.- 6 Electrophysiology of the Enteric Neurons.- A. Introduction.- B. Extracellular Recording Techniques.- C. Intracellular Recording Techniques.- D. Actions of Endogenous and Exogenous Substances on Enteric Neurons.- E. Functional Roles of Enteric Neurons in the Control of Gastrointestinal Motility.- References.- 7 In Vivo Techniques for the Study of Gastrointestinal Motility.- A. Introduction.- B. Techniques for the Study of Wall Movements.- C. Techniques for the Study of Intraluminal Pressure.- D. Techniqes for the Study of Transit of Contents.- E. Use of Combined Techniques.- References.- 8 In Vitro Techniques for the Study of Gastrointestinal Motility.- A. Introduction.- B. General Methodology.- C. Muscle Segments and Strips.- D. Gastric Motility.- E. Intestinal Peristalsis.- F. Effects of Stretch on Muscle Strips.- G. Electrical Stimulation of Autonomic Nerves.- H. Conclusions.- References.- 9 Nervous Control of Esophageal and Gastric Motility.- A. Nervous Control of the Esophagus.- B. Nervous Control of the Stomach.- References.- 10 Nervous Control of Intestinal Motility.- A. Introduction.- B. Neuromuscular Transmission in the Intestine.- C. Transmission and Pathways in Enteric Ganglia.- D. Initiation of Sensory Inputs in the Intestine.- E. Electrical Stimulation of Extrinsic Nerves.- F. Conclusions on Neuromuscular and Ganglionic Transmission in the Intestine.- G. Patterns of Motility of the Intestine.- H. Nervous Control of Intestinal Motility.- J. Role of Intrinsic Nerves in the Pattern of Intestinal Motility in the Freely Fed State.- K. Extrinsic Intestinal (Intestinointestinal) Reflexes.- L. General Summary and Conclusions.- References.- Note Added in Proof.- 11 Identification of Gastrointestinal Neurotransmitters.- A. Criteria for Transmitter Identification and Their Application to the Intestine.- B. Evidence that a Number of Different Neurotransmitters are Released in the Gastrointestinal Tract.- C. Identification of Acetylcholine as an Intestinal Transmitter.- D. Noradrenaline as an Intestinal Transmitter.- E. Evidence For and Against 5-Hydroxytryptamine.- F. Evidence For and Against Dopamine.- G. Evidence that ?-Aminobutyric Acid is a Neurotransmitterin the Intestine.- H. Identification of the Transmitter Released from Enteric Inhibitory Nerves.- J. Peptides as Intestinal Transmitters.- K. Summary.- Note Added in Proof.- References.mehr