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New Neuromuscular Blocking Agents

Basic and Applied Aspects
BuchKartoniert, Paperback
744 Seiten
Englisch
Springererschienen am13.12.2011Softcover reprint of the original 1st ed. 1986
The problems associated with the pharmacologic and physiologic regulation of neuromuscular transmission and of the morphofunctional organization of neuromuscular junctions have attracted a wide range of investigators.mehr

Produkt

KlappentextThe problems associated with the pharmacologic and physiologic regulation of neuromuscular transmission and of the morphofunctional organization of neuromuscular junctions have attracted a wide range of investigators.
Zusammenfassung
Details
ISBN/GTIN978-3-642-70684-4
ProduktartBuch
EinbandartKartoniert, Paperback
Verlag
Erscheinungsjahr2011
Erscheinungsdatum13.12.2011
AuflageSoftcover reprint of the original 1st ed. 1986
ReiheHandbook of Experimental Pharmacology
Seiten744 Seiten
SpracheEnglisch
Gewicht1305 g
IllustrationenXXIV, 744 p.
Artikel-Nr.18232054
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
1 Neuromuscular Blocking Agents: General Considerations.- 2 The End-Plate Acetylcholine Receptors: Structure and Function.- A. Introduction.- B. Molecular Properties of the Acetylcholine Receptor.- C. The 43K Protein.- D. Multiple Binding Sites and Multiple Affinity States.- E. Three-Dimensional Structure.- F. Biochemical Control Over Receptor Activity: Phosphorylation, Methylation, and Glycosylation.- G. Summary and Conclusions.- References.- Pharmacodynamics and Pharmacokinetics of Neuromuscular Blocking Agents.- 3 On the Principles of Postsynaptic Action of Neuromuscular Blocking Agents.- 4 On the Hydrophobic Interaction of Neuromuscular Blocking Agents with Acetylcholine Receptors of Skeletal Muscles.- 5 Prejunctional Actions of Cholinoceptor Agonists and Antagonists, and of Anticholinesterase Drugs.- 6 On the Comparative Sensitivity of Acetylcholine Receptors of Various Groups of Skeletal Muscles to Neuromuscular Blocking Agents.- 7 Antimuscarinic and Ganglion-Blocking Activity of Neuromuscular Blocking Agents.- 8 The Interaction of Neuromuscular Blocking Agents With Human Cholinesterases and Their Binding to Plasma Proteins.- 9 On the Effect of Neuromuscular Blocking Agents on the Central Nervous System.- 10 Biodegradation and Elimination of Neuromuscular Blocking Agents.- On the Relationship Between the Chemical Structure and the Neuromuscular Blocking Activity.- 11 Methods for the Experimental Evaluation of Neuromuscular Blocking Agents.- 12 Steroid Derivatives.- 13 The Derivatives of Carboxylic Acids.- 14 Quinuclidinium Compounds.- 15 Derivatives of Terphenyl..- 16 Delphinium Alkaloids.- Preclinical Pharmacology of New Neuromuscular Blocking Drugs.- 17 Bisquaternary Steroid Derivatives.- 18 Vecuronium (ORG-NC-45).- 19 The Derivatives of ?-Truxillic Acid.- 20Adamantyl Compounds.- 21 Tercuronium..- 22 Dioxonium..- 23 Fazadinium Dibromide..- 24 Atracurium.- Clinical Pharmacology of New Neuromuscular Blocking Drugs.- 25 General Principles and Methods of Evaluation of Neuromuscular Blocking Agents in Anesthesiology.- 26 Neuromuscular Blocking Agents of Different Chemical Structure.- 27 Pipecuronium Bromide (Arduan)..- 28 Vecuronium (ORG-NC-45)..- 29 Fazadinium Dibromide.- 30 Atracurium.- Antagonists of Neuromuscular Blocking Agents (Pharmacology and Clinical Use).- 31 Galanthamine..- 32 Chinothylinum..- 33 4-Aminopyridine Hydrochloride (Pymadin).- Subject Index V.V. Maisky.mehr