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Molecular identification of the CTX-M resistance gene in bacteria

Bacterial resistance - Großformatiges Paperback. Klappenbroschur
BuchKartoniert, Paperback
52 Seiten
Englisch
Our Knowledge Publishingerschienen am20.07.2024
The CTX-M resistance gene produces Extended Spectrum Beta-lactamase (ESBL) enzymes that are capable of inhibiting the action of broad-spectrum beta-lactam antimicrobials by irreversibly hydroxylating the amide bond of the beta-lactam ring of these antimicrobials. In general, the gene that codes for ESBLs is located on plasmids, and these enzymes are characterised by their ability to inactivate beta-lactam antimicrobials such as penicillins, cephalosporins and monobactams, with the exception of carbapenems. Its hydrolytic action towards antimicrobials can be interrupted with the use of beta-lactamase inhibitors such as clavulanic acid, sulbactam and tazobactam. The CTX-M gene originated from the mobilisation of beta-lactam resistance genes present in the chromosomes of Kluyvera spp. bacteria, which from point mutations derived into different subtypes of the gene, in response to the selective pressure intensified by the widespread indiscriminate use of beta-lactam antimicrobials.mehr

Produkt

KlappentextThe CTX-M resistance gene produces Extended Spectrum Beta-lactamase (ESBL) enzymes that are capable of inhibiting the action of broad-spectrum beta-lactam antimicrobials by irreversibly hydroxylating the amide bond of the beta-lactam ring of these antimicrobials. In general, the gene that codes for ESBLs is located on plasmids, and these enzymes are characterised by their ability to inactivate beta-lactam antimicrobials such as penicillins, cephalosporins and monobactams, with the exception of carbapenems. Its hydrolytic action towards antimicrobials can be interrupted with the use of beta-lactamase inhibitors such as clavulanic acid, sulbactam and tazobactam. The CTX-M gene originated from the mobilisation of beta-lactam resistance genes present in the chromosomes of Kluyvera spp. bacteria, which from point mutations derived into different subtypes of the gene, in response to the selective pressure intensified by the widespread indiscriminate use of beta-lactam antimicrobials.
Details
ISBN/GTIN978-620-7-84973-4
ProduktartBuch
EinbandartKartoniert, Paperback
Erscheinungsjahr2024
Erscheinungsdatum20.07.2024
Seiten52 Seiten
SpracheEnglisch
Artikel-Nr.61801289

Autor

Bachelor's degree in Biological Sciences with an emphasis on Molecular, Structural and Functional Biology. She was awarded a Proacadêmico scholarship, where she handled laboratory reagents and equipment and Molecular Biology procedures. She was a member of the Diagnostic Procedures in Molecular Biology, Biochemistry and Immunology research group at UFRR.