Translation and Its Regulation in Cancer Biology and Medicine

von

Herausgegeben:Parsyan, Armen

BuchGebunden

697 Seiten

Englisch

Springer Netherlandserschienen am27.10.2014

Translation and Its Regulation in Cancer Biology and Medicinemehr

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Produkt

KlappentextTranslation and Its Regulation in Cancer Biology and Medicine

Details

ISBN/GTIN978-94-017-9077-2

ProduktartBuch

EinbandartGebunden

Verlag

Springer Netherlands

Erscheinungsjahr2014

Erscheinungsdatum27.10.2014

Seiten697 Seiten

SpracheEnglisch

Gewicht1326 g

IllustrationenXXXIV, 697 p. 52 illus., 44 illus. in color.

Artikel-Nr.31540275

Rubriken

GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis

Preface.- Introduction.- PART I. TRANSALATION MACHINERY IN CANCER.- Mechanism of Translation in Eukaryotes.- Diverse Mechanisms of Translation Regulation and Their Role in Cancer.- eIF4E and Its Binding Proteins.- RNA Helicases and Their Cofactors.- PDCD4.- eIF4G.- eIF3.- The eIF2 Complex and eIF2Î±.- eIF5A.- eIF6.- Translation Elongation.- Ribosomes.- Current and Emerging Therapies Targeting Translation.- PART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER.- mTOR and Regulation of Translation.- Ribosomal Protein S6 and S6 Kinases.- eIF4E Phosphorylation Downstream of MAPK Pathway.- PART III. CELL FATE AND TRANSLATION IN CANCER.- Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells.- Translation and Apoptosis in Cancer.- Translation in Cancer at Hypoxia.- PART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES.- Melanoma and Non-Melanoma Skin Cancers.- Sarcomas.- Hematological Malignancies and Premalignant Conditions.- Brain Tumors.- Head and Neck Cancers.- Breast Cancer.- Cancers of the Respiratory System.- Gastric and Esophageal Cancers.- Colorectal Cancers.- Hepatic, Pancreatic and Biliary Cancers.- Pancreatic Neuroendocrine Tumors.- Gynecologic Cancers.- Prostate Cancer.- Cancers of the Urinary System.- List of Abbreviations.mehr