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Sirtuins

Previously published in hardcover
BuchKartoniert, Paperback
288 Seiten
Englisch
Springer Netherlandserschienen am05.07.2018Softcover reprint of the original 1st ed. 2016
The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer.mehr
Verfügbare Formate
BuchKartoniert, Paperback
EUR160,49
BuchGebunden
EUR160,49

Produkt

KlappentextThe sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer.
Zusammenfassung
Key leaders in the field of sirtuin biology share their expertise

Covers a wide variety of physiological processes controlled by sirtuin proteins

Offers new insights into how sirtuin proteins can be targeted to treat age-related diseases

Includes supplementary material: sn.pub/extras
Details
ISBN/GTIN978-94-024-1450-9
ProduktartBuch
EinbandartKartoniert, Paperback
Erscheinungsjahr2018
Erscheinungsdatum05.07.2018
AuflageSoftcover reprint of the original 1st ed. 2016
ReiheProteins and Cell Regulation
Seiten288 Seiten
SpracheEnglisch
Gewicht506 g
IllustrationenVIII, 288 p. 30 illus., 24 illus. in color.
Artikel-Nr.45666122
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
General introduction, Riekelt H. Houtkooper.- Biochemistry and Enzymology of Sirtuins, Yue Yang and Anthony A. Sauve.- NAD+ as a pharmacological tool to boost sirtuin activity, Riekelt H. Houtkooper.- Protein lysine acylation: abundance, dynamics and function, Olga Pougovkina and Vincent C. J. de Boer.- SIRT1 in metabolic health and disease, Marie Boutant and Carles Cantó.- Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function, Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey.- SIRT5 reveals novel enzymatic activities of sirtuins, Bin He and Hening Lin.- Diverse roles for SIRT6 in mammalian healthspan and longevity, Bernadette M. M. Zwaans, William Giblin and David B. Lombard.- Sirtuins in cancer - emerging role as modulators of metabolic reprogramming, Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis.- Sirtuins as metabolic modulators of muscle plasticity, Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx.- Sirtuins and aging, Carles Cantó and Riekelt Houtkooper.- Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk, Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi.- Sirtuin activation by small molecules, Hassina Massudi, Lindsay E. Wu, and David A. Sinclair.- Future perspective, Brian Kennedy.- Index.mehr