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The Amide Linkage

Structural Significance in Chemistry, Biochemistry, and Materials Science
BuchGebunden
672 Seiten
Englisch
Wileyerschienen am26.01.2000
This text presents specific applications to supramolecular and stereospecific synthesis. It discusses aspects of peptide and protein chemistry as well as highlighting how the amide linkage participates in the design of enzyme inhibitors, cyclic peptides and antibacterial agents.mehr

Produkt

KlappentextThis text presents specific applications to supramolecular and stereospecific synthesis. It discusses aspects of peptide and protein chemistry as well as highlighting how the amide linkage participates in the design of enzyme inhibitors, cyclic peptides and antibacterial agents.
Details
ISBN/GTIN978-0-471-35893-0
ProduktartBuch
EinbandartGebunden
FormatGenäht
Verlag
Erscheinungsjahr2000
Erscheinungsdatum26.01.2000
Seiten672 Seiten
SpracheEnglisch
MasseBreite 165 mm, Höhe 243 mm, Dicke 39 mm
Gewicht1061 g
Artikel-Nr.11991046

Inhalt/Kritik

Inhaltsverzeichnis
The Electron Density Distribution of Amides and Related Compounds (C. Breneman & M. Martinov). Origin of the Amide Rotational Barrier (K. Wiberg). The Amide Linkage as a Ligand-Its Properties and the Role of Distortion (A. Greenberg). Studies in Amide Hydrolysis: The Acid, Base, and Water Reactions (R. Brown). The Thermochemistry of Amides (J. Liebman, et al.). Stereospecificity in the -Lactam (Aziridinone) Synthon (R. Hoffman). -Lactams: Cyclic Amides of Distinction (A. Bose, et al.). Sterically Hindered Twisted Amides (S. Yamada). Photoelectron Spectroscopy of Amides and Lactams (P. Rademacher). The Role of Amides in the Noncovalent Synthesis of Supramolecular Structures in Solution, at Interfaces, and in Solids (G. Palmore & J. MacDonald). -Lactam Antibacterial Agents: Computational Chemistry Investigations (D. Boyd). Three-Dimensional Design of Enzyme Inhibitors with Heterocyclic Amide Bond Mimics (R. Bohacek & W. Shakespeare). Ab Initio Conformational Analysis of Protein Subunits: A Case Study of the Serine Diamide Model (A. Perczel & I. Csizmadia). Gas-Phase Ion Chemistry of Amides, Peptides, and Proteins (C. Cassady). -Sheet Interactions Between Proteins (S. Maitra & J. Nowick). Head-to-Tail Cyclic Peptides and Cyclic Peptide Libraries (A. Spatola & P. Romanovskis). From Crystal Structures of Oligopeptides to Protein Folding. The Importance of Peptide Bond-Side Chain Hyperconjugation (A. Cieplak). Role of the Peptide Bond in Protein Structure and Folding (N. Kallenbach, et al.). Index.mehr
Kritik
"It makes extremely interesting reading" (Angewandte Chemie, International Edition 19 November 2001)mehr

Autor

ARTHUR GREENBERG, PhD, is Professor in the Department of Chemistry at the University of New Hampshire.
CURT M. BRENEMAN, PhD, is Professor in the Department of Chemistry at Rensselaer Polytechnic Institute.
JOEL F. LIEBMAN, PhD, is Professor in the Department of Chemistry and Biochemistry at the University of Maryland, Baltimore County.
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