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Antibody Expression and Production

BuchGebunden
346 Seiten
Englisch
Springer Netherlandserschienen am18.05.2011
Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.mehr
Verfügbare Formate
BuchGebunden
EUR213,99
BuchKartoniert, Paperback
EUR213,99
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Produkt

KlappentextEngineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.
Zusammenfassung
Detailed background for antibody generation and production

Chapters on production of antibody in bacterial, fungal, mammalian, insects and transgenic animal and plants

Scientific and technical approaches to accelerating the development of robust upstream and downstream processes

Identify the limitations in developing processes for antibody production
Details
ISBN/GTIN978-94-007-1256-0
ProduktartBuch
EinbandartGebunden
Erscheinungsjahr2011
Erscheinungsdatum18.05.2011
Seiten346 Seiten
SpracheEnglisch
Gewicht707 g
IllustrationenX, 346 p.
Artikel-Nr.11452741
Rubriken
GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis
1 Expression of antibody in mammalian cells, Thomas Jostock.- 2 Bioreactor systems for producing antibody from mammalian cells, Darrin Kuystermans and Mohamed Al-Rubeai.- 3 Production of antibody in insect cells, Hideki Yamaji.- 4 Production of monoclonal antibodies in glycoengineered Pichia pastoris, Dongxing Zhu, Thomas Linden and Thomas Potgieter.- 5 Production of antibodies in Hansenula polymorpha, Georg Melmer, Stephan Hellwig, Grit Hehmann and Ulrike Dahlems.- 6 Expression of antibody in transgenic avians, Yoshinori Kawabe and Masamichi Kamihira.- 7 Production of antibodies in plants, Alejandro Sarrion-Perdigones, Paloma Juarez, Antonio Granell and Diego Orzaez.- 8 Production of antibody fab fragments in Escherichia coli, Hiroshi Tachibana and Masataka Takekoshi.- 9 Intrabody expression in mammalian cells, Silvia Biocca.- 10 Engineering of antibodies for cancer therapy, Lisa E. Goldsmith and Matthew K. Robinson.- 11 Recombinant bispecific antibodies for cancer therapy, Dafne Muller and Roland Kontermann.- 12 The role of glycosylation in therapeutic antibodies, Maureen Spearman, Ben Dionne and Mike Butler.- 13 Quality issues arising from post-translational modification of recombinant antibodies, Raymond Tyther and Nigel Jenkins.- 14 Purification of antibody, XueJun Han, Arther Hewig and Ganesh Vedantham.- Indexmehr