Mouse as a Model Organism

From Animals to Cells - Previously published in hardcover

von

Herausgegeben:Brakebusch, CordPihlajaniemi, Taina

BuchKartoniert, Paperback

165 Seiten

Englisch

Springer Netherlandserschienen am16.10.20142011

Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described.mehr

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KlappentextAmong other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described.

ZusammenfassungThis fascinating book offers an introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It highlights the possibilities, but also discusses the current problems in this field.

Details

ISBN/GTIN978-94-007-9609-6

ProduktartBuch

EinbandartKartoniert, Paperback

Verlag

Springer Netherlands

Erscheinungsjahr2014

Erscheinungsdatum16.10.2014

Auflage2011

Seiten165 Seiten

SpracheEnglisch

Gewicht284 g

IllustrationenXIV, 165 p.

Artikel-Nr.33147561

Rubriken

GenreMedizin

Inhalt/Kritik

Inhaltsverzeichnis

Preface.- 1 Genomic insulators in transgenic animals, Lluís Montoliu et al.- 2 The GERMAN MOUSE CLINIC - Running an open access platform, Martin Hrabé de Angelis et al..- 3 Nature & Nurture: impacts on mouse phenotypes & translational research, Cory Brayton.- 4 X The informatics of high-throughput mouse phenotyping: EUMODIC and beyond, John M Hancock and Hilary Gates.- 5 Experimental tumour models in mice, Ritva Heljasvaara and Taina Pihlajaniemi.- 6 Exploration of MMP function in mouse models of angiogenesis, Agnès NOEL et al..- 7 Tumor- stroma interactions: focus on fibroblasts, Donald Gullberg and Rolf K. Reed.- 8 Experimental procedures to assay invasion-associated activities of primary cultured fibroblasts, Olivier De Wever et al..- 9 Systemic Instigation: A Mouse Model to Study Breast Cancer as a Systemic Disease, Sandra S. McAllister.- Indexmehr

Kritik

"The book gives a good introduction to the possible way of exploiting the mouse system to explore the molecular pathways underlying human diseases, especially cancer. The concept of 'mouse clinics' and the high throughput phenotyping of mouse mutants ... described in the books will be watched with bated breath by all investigators of biomedical research, as these are the signposts of things to come in future." (N. V. Giridharan, Indian Journal of Medical Research, Vol. 136, October, 2012)mehr